Gemcitabine PhaRes 200 mg/vial (IV Infusion)

200 mg vial: ৳ 2,110.00

Medicine Details

Category Details
Generic Gemcitabine
Company Thymoorgan pharmazie gmbh germany
Also available as
Gemcitabine phares 1 gm injection

Indications

  • Non-Small Cell Lung Cancer
  • Pancreatic Cancer
  • Bladder Cancer
  • Breast Cancer
  • Ovarian Cancer

Pharmacology

  • Metabolised intracellularly by nucleoside kinases
  • Cytotoxic action due to inhibition of DNA synthesis
  • Inhibition of ribonucleotide reductase
  • Competes with dCTP for incorporation into DNA
  • Induces programmed cellular death process

Dosage & Administration

  • Recommended dose of Gemcitabine for Non-Small Cell Lung Cancer
  • Recommended dose of Gemcitabine for Pancreatic Cancer
  • Recommended dose of Gemcitabine for Bladder Cancer
  • Recommended dose of Gemcitabine for Breast Cancer
  • Recommended dose of Gemcitabine for Ovarian Cancer

Interaction

  • No confirmed interactions reported
  • No specific drug interaction studies conducted

Contraindications

  • Contraindicated in patients with known hypersensitivity to Gemcitabine

Side Effects

  • Haematological Toxicity
  • Hepatic Toxicity
  • Gastrointestinal effects
  • Genito-Urinary Toxicity
  • Pulmonary Toxicity
  • Allergic Toxicity
  • Neurotoxicity
  • Alopecia

Pregnancy & Lactation

  • Pregnancy Category D
  • Use during pregnancy
  • Unknown excretion in human breast milk

Precautions & Warnings

  • Caution in patients with risk of Schedule-dependent Toxicity
  • Caution in patients with Myelosuppression
  • Caution in patients with Pulmonary Toxicity and Respiratory Failure
  • Caution in patients with Hemolytic Uremic Syndrome
  • Caution in patients with Hepatic Toxicity
  • Caution in patients with Embryofetal Toxicity
  • Caution in patients undergoing Radiation Therapy
  • Caution in patients with Impairment of Fertility

Use in Special Populations

  • Elderly Patients
  • Renal and Hepatic Impairment
  • Children

Overdose Effects

  • No known antidote for overdoses
  • Principal toxicities seen with high doses

Therapeutic Class

  • Cytotoxic Chemotherapy

Storage Conditions

  • Store vial in original carton at 20°C to 25°C
  • Do not refrigerate as crystallisation may occur
  • Keep out of the reach of children

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