Irinotecan PhaRes 20 mg/ml (IV Infusion)

100 mg vial: ৳ 4,946.00

Medicine Details

Category Details
Generic Irinotecan hydrochloride
Company Thymoorgan pharmazie gmbh germany

Indications

  • First-line therapy for metastatic carcinoma of the colon or rectum
  • Treatment for recurrent or progressed disease following initial Fluorouracil-based therapy

Pharmacology

  • Derivative of Camptothecin
  • Interacts with topoisomerase I
  • Prevents religation of single-strand breaks in DNA

Dosage & Administration

  • Multiple combination regimens for colorectal cancer
  • Dosage based on body surface area
  • Different infusion schedules for single-agent regimens

Interaction

  • Increased risk of dehydration with diuretics
  • Enhanced lymphocytopenia with prophylactic dexamethasone
  • Increased incidence of akathisia with prochlorperazine
  • Possible reduction in exposure with St John's wort and ketoconazole

Contraindications

  • Hypersensitivity to the drug or its excipients

Side Effects

  • Nausea
  • Vomiting
  • Abdominal pain
  • Diarrhea
  • Constipation
  • Anorexia
  • Mucositis
  • Neutropenia
  • Leukopenia
  • Anemia
  • Thrombocytopenia
  • Asthenia
  • Pain
  • Fever
  • Infection
  • Abnormal bilirubin
  • Alopecia

Pregnancy & Lactation

  • Pregnancy category D
  • Potential fetal harm
  • Potential excretion in human milk

Precautions & Warnings

  • Cholinergic reactions with early diarrhea
  • Possible cholinergic symptoms
  • Preventive and therapeutic measures for cholinergic symptoms
  • Life-threatening late diarrhea
  • Risk of myelosuppression and neutropenic fever
  • Increased risk for neutropenia in individuals with reduced UGT1A1 activity

Use in Special Populations

  • Effectiveness in pediatric patients not established
  • Greater risk of early and late diarrhea in geriatric patients
  • Caution in patients with renal impairment
  • Diminished clearance in hepatic impairment

Therapeutic Class

  • Cytotoxic Chemotherapy

Storage Conditions

  • Store at controlled room temperature 15°C to 30°C
  • Protect from light
  • Keep the vial in the carton until the time of use

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