Bendafolin 10 mg/ml (IM/IV Injection)
200 mg vial: ৳ 2,550.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Folinic acid |
| Company | Solupharm gmbh germany |
Indications
- Neutralising the immediate toxic effects of folic acid antagonists, e.g. methotrexate
- Calcium folinate rescue- a treatment technique using calcium folinate in conjunction with folic acid antagonists, e.g. methotrexate, to minimise systemic toxicity
- The treatment of megaloblastic anaemias due to sprue, nutritional deficiency, pregnancy, infancy, liver disease and malabsorption syndrome
Composition
- 6.249 mg Calcium Folinate Hydrate BP equivalent to 5 mg Folinic Acid
- 18.746 mg Calcium Folinate Hydrate BP equivalent to 15 mg Folinic Acid
Pharmacology
- Metabolite and active form of folic acid
- Cofactor for 1-carbon transfer reactions in the biosynthesis of purine and pyrimidines of nucleic acids
- Potent antidote for both hematopoietic and reticuloendothelial toxic effects of folic acid antagonists
- Ready conversion to other tetrahydrofolic acid derivatives
- Principle behind high-dose methotrexate therapy with "Folinate rescue"
Dosage & Administration
- Calcium folinate rescue dosage regimen
- Dosage for neutralising the immediate toxic effects of folic acid antagonists
- Dosage for megaloblastic anaemia (folate deficiency)
- Use in children and adolescents
Interaction
- Counteraction of antiepileptic effect of phenobarbitone, phenytoin and primidone
- Increase in frequency of seizures in susceptible patients during concurrent administration with fluoropyrimidine
Contraindications
- Known hypersensitivity to calcium folinate or any other components of the product
- Pernicious anemia or other megaloblastic anemia where vitamin B12 is deficient
- Rare hereditary problems of galactose intolerance, lapp lactase deficiency or glucose-galactose malabsorption
Side Effects
- Mucositis
- Stomatitis
- Leukopenia
- Diarrhea
Pregnancy & Lactation
- Use in pregnant women
- Excretion in human milk
Precautions & Warnings
- Use with methotrexate or 5-FU under the direct supervision of a clinician experienced in the use of cancer chemotherapeutic agents
- Administration as soon as possible for inadvertent overdosage of a folic acid antagonist
- Avoid simultaneous administration with folic acid antagonists
- Measures to ensure prompt excretion of methotrexate as part of Calcium Folinate Rescue Therapy
Overdose Effects
- Nullity of the chemotherapeutic effect of folic acid antagonists
- No specific antidote to calcium folinate overdose
- Appropriate supportive care for overdosage
Therapeutic Class
- Supportive Care Therapy
Storage Conditions
- Do not store above 30°C
- Keep away from light
- Keep out of the reach of children