Cisplatin PhaRes 1 mg/ml (IV Infusion)
10 mg vial: ৳ 735.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Cisplatin |
| Company | Pharma resources |
Indications
- Metastatic Testicular Tumors
- Metastatic Ovarian Tumors
- Advanced Bladder Cancer
- Small Cell Lung Carcinoma
Pharmacology
- Platinum compound
- Inhibits DNA synthesis
- Intra-and interstrand cross links
- Inhibits protein and RNA synthesis
Dosage & Administration
- Administered by slow intravenous infusion
- Dosage varies for different indications
- Not to be given by rapid intravenous injection
- Reacts with aluminum parts
Interaction
- Used in combination with antineoplastic drugs
- Additive toxicity likely with similar drugs
- Known drug interactions with nephrotoxic drugs, ototoxic drugs, renally excreted drugs, anticonvulsant agents, antigout agents
Contraindications
- Pre-existing renal impairment
- Hypersensitivity to Cisplatin or Platinum containing compounds
- Myelosuppressed patients
- Patients with hearing impairment
Side Effects
- Severe nausea and vomiting
- Electrolyte disturbances
- Renal tubular dysfunction
- Hypomagnesemia, hypocalcemia, hypokalemia
- Potential ototoxicity
Pregnancy & Lactation
- Pregnancy Category D
- No adequate and well controlled studies in pregnant women
- Cisplatin found in human milk
Precautions & Warnings
- Cumulative nephrotoxicity
- Renal function and serum electrolyte evaluation
- Peripheral blood counts monitoring
- Audiometry for ototoxicity
- Neurotoxicity monitoring
- Nausea and vomiting management
- Carcinogenicity risk
- Increased incidence of microbial infection and delayed healing
- Dental work precautions
Overdose Effects
- Kidney failure
- Liver failure
- Deafness
- Ocular toxicity
- Myelosuppression
- Intractable nausea and vomiting
- Neuritis
Therapeutic Class
- Cytotoxic Chemotherapy
Storage Conditions
- Store at 25°C
- Do not refrigerate
- Protect from light
- Keep out of reach of children