Norma-H 150 mg (Tablet)
Unit Price: ৳ 2.50 (10 x 10: ৳ 250.00)
Strip Price: ৳ 25.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Ranitidine hydrochloride |
| Company | Renata limited |
Indications
- Treatment of active duodenal ulcer
- Benign gastric ulcer
- Prevention of ulcer associated with non-steroidal anti-inflammatory agent
- Post operative stress ulcer
- Zollinger-Ellison Syndrome
- Gastroesophageal reflux disease (GERD)
- Gastro-intestinal hemorrhage from stress ulcer in seriously ill patient
- Recurrent hemorrhage in patients with bleeding peptic ulcer
- Before general anesthesia in patient considered to be at risk of acid aspiration
- Treatment and prevention of ulcer associated with non-steroidal anti-inflammatory agent
Pharmacology
- Competitively blocks histamine at H2-receptors
- Inhibits gastric acid secretion
- Does not affect pepsin secretion or serum gastrin
Dosage and Administration
- Usual dosage of 150 mg twice daily for active duodenal and gastric ulcer
- 300 mg as a single daily dose at night for 4 to 8 weeks for duodenal and gastric ulcer
- 150 mg twice daily for reflux esophagitis
- 300 mg at bedtime for up to 8 weeks for reflux esophagitis
- 150 mg 3 times daily for Zollinger Ellison syndrome
- 150 mg twice daily for episodic dyspepsia
- 300 mg at bedtime for up to 6 weeks for episodic dyspepsia
- 150 mg at night for maintenance to prevent recurrences
- Ranitidine IV injection given as a slow intravenous injection of 50 mg
Interaction
- Delayed absorption and increased peak serum concentration with propantheline bromide
- Minimally inhibits hepatic metabolism of certain drugs
- May alter absorption of pH-dependent drugs
- May reduce bioavailability with antacids
Contraindications
- Hypersensitivity to Ranitidine
Side Effects
- Altered bowel habit
- Dizziness
- Rash
- Tiredness
- Reversible confusional states
- Headache
- Decreased blood counts
- Muscle or joint pain
Pregnancy and Lactation
- Crosses the placenta
- No evidence of impaired fertility or harm to the fetus
- Excreted in human breast milk
Precautions and Warnings
- Given in reduced dosage to patients with impaired renal and hepatic function
Use in Special Populations
- Similar ulcer healing rates in patients age 65 and over
- No difference in the incidence of adverse effects
Overdose Effects
- Highly specific in action
- No particular problems expected following overdosage
- Symptomatic and supportive therapy should be given as appropriate
- May be removed from the plasma by haemodialysis if required
Therapeutic Class
- H2 receptor antagonist
Reconstitution
- Slow IV injection of 50 mg diluted to a concentration less than or equal to 2.5 mg/mL
- Intermittent slow IV infusion of 50 mg diluted to a concentration less than or equal to 0.5 mg/mL
- Continuous IV infusion of 150 mg diluted in 250 mL of dextrose 5% inj or NaCl 0.9%
- Norma-H should be diluted to a concentration less than or equal to 2.5 mg/mL for patients with hypersecretory conditions
Storage Conditions
- Store in a cool and dry place
- Protect from light