Geficent 250 mg (Tablet)

Unit Price: ৳ 120.00 (1 x 10: ৳ 1,200.00)
Strip Price: ৳ 1,200.00

Medicine Details

Category Details
Generic Gefitinib
Company Incepta pharmaceuticals ltd

Indications

  • First-line treatment for metastatic non-small cell lung cancer
  • Treatment for tumors with specific EGFR mutations
  • FDA-approved test for mutation detection

Pharmacology

  • Reversible inhibition of EGFR kinase activity
  • Prevention of autophosphorylation of tyrosine residues
  • Inhibition of downstream signaling
  • Higher binding affinity for specific EGFR mutations
  • Inhibition of IGF and PDGF-mediated signaling
  • Partial inhibition of other tyrosine kinase receptors

Dosage & Administration

  • Recommended oral dose of 250 mg once daily
  • Can be taken with or without food
  • Special administration for patients with difficulty swallowing solids
  • Instructions for missed doses

Interaction

  • Interactions with CYP3A4 inducers and inhibitors
  • Adjustment of dosage in the presence of strong CYP3A4 inducers
  • Increased or decreased plasma concentrations

Contraindications

  • Contraindicated in patients with known hypersensitivity to Gefitinib

Side Effects

  • Common side effects including interstitial lung disease, hepatotoxicity, gastrointestinal perforation, diarrhea, ocular disorders, and skin disorders

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • Potential hazard to the fetus
  • Unknown excretion in human milk
  • Advice to discontinue breastfeeding during treatment

Precautions & Warnings

  • Monitoring and investigation for ILD or ILD-like adverse reactions
  • Periodic liver function testing
  • Should be withheld or discontinued in case of severe adverse reactions

Use in Special Populations

  • Safety and effectiveness in pediatric patients not established
  • Monitoring adverse reactions in patients with renal impairment
  • Monitoring adverse reactions in patients with hepatic impairment

Therapeutic Class

  • Targeted Cancer Therapy

Storage Conditions

  • Store between 20-25°C
  • Cool, dry place
  • Away from sunlight
  • Keep out of the reach of children

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