Geficent 250 mg (Tablet)
Unit Price: ৳ 120.00 (1 x 10: ৳ 1,200.00)
Strip Price: ৳ 1,200.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Gefitinib |
| Company | Incepta pharmaceuticals ltd |
Indications
- First-line treatment for metastatic non-small cell lung cancer
- Treatment for tumors with specific EGFR mutations
- FDA-approved test for mutation detection
Pharmacology
- Reversible inhibition of EGFR kinase activity
- Prevention of autophosphorylation of tyrosine residues
- Inhibition of downstream signaling
- Higher binding affinity for specific EGFR mutations
- Inhibition of IGF and PDGF-mediated signaling
- Partial inhibition of other tyrosine kinase receptors
Dosage & Administration
- Recommended oral dose of 250 mg once daily
- Can be taken with or without food
- Special administration for patients with difficulty swallowing solids
- Instructions for missed doses
Interaction
- Interactions with CYP3A4 inducers and inhibitors
- Adjustment of dosage in the presence of strong CYP3A4 inducers
- Increased or decreased plasma concentrations
Contraindications
- Contraindicated in patients with known hypersensitivity to Gefitinib
Side Effects
- Common side effects including interstitial lung disease, hepatotoxicity, gastrointestinal perforation, diarrhea, ocular disorders, and skin disorders
Pregnancy & Lactation
- No adequate and well-controlled studies in pregnant women
- Potential hazard to the fetus
- Unknown excretion in human milk
- Advice to discontinue breastfeeding during treatment
Precautions & Warnings
- Monitoring and investigation for ILD or ILD-like adverse reactions
- Periodic liver function testing
- Should be withheld or discontinued in case of severe adverse reactions
Use in Special Populations
- Safety and effectiveness in pediatric patients not established
- Monitoring adverse reactions in patients with renal impairment
- Monitoring adverse reactions in patients with hepatic impairment
Therapeutic Class
- Targeted Cancer Therapy
Storage Conditions
- Store between 20-25°C
- Cool, dry place
- Away from sunlight
- Keep out of the reach of children