Folicid 10 mg/ml (IM/IV Injection)
50 mg vial: ৳ 600.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Folinic acid |
| Company | Techno drugs ltd |
Indications
- Neutralising the immediate toxic effects of folic acid antagonists, e.g. methotrexate
- Calcium folinate rescue- a treatment technique using calcium folinate in conjunction with folic acid antagonists, e.g. methotrexate, to minimise systemic toxicity
- The treatment of megaloblastic anaemias due to sprue, nutritional deficiency, pregnancy, infancy, liver disease and malabsorption syndrome
Composition
- Each tablet contains- Calcium Folinate Hydrate BP 6.249 mg equivalent to Folinic Acid 5 mg
- Each tablet contains- Calcium Folinate Hydrate BP 18.746 mg equivalent to Folinic Acid 15 mg
Pharmacology
- Involved as a cofactor for 1-carbon transfer reactions in the biosynthesis of purine and pyrimidines of nucleic acids
- Potent antidote for hematopoietic and reticuloendothelial toxic effects of folic acid antagonists
Dosage & Administration
- Calcium folinate rescue treatment should commence approximately 24 hours after the beginning of methotrexate infusion
- Folinic Acid should be administered at a dose of 15 mg (approximately 10 mg/m2) every 6 hours for 10 doses
Interaction
Folinates given in large amounts may counteract the antiepileptic effect of phenobarbitone, phenytoin and primidone
Contraindications
- Known hypersensitivity to calcium folinate or any other components of this product
- Pernicious anemia or other megaloblastic anemia where vitamin B12 is deficient
Side Effects
- Mucositis
- Stomatitis
- Leukopenia
- Diarrhea
Pregnancy & Lactation
- Should only be used in pregnant women if the potential benefit justifies the potential risk to the fetus
- Caution should be exercised when calcium folinate is administered to a nursing mother
Precautions & Warnings
Should only be used with methotrexate or 5-FU under the direct supervision of a clinician experienced in the use of cancer chemotherapeutic agents
Overdose Effects
- Excessive amounts of calcium folinate may nullify the chemotherapeutic effect of folic acid antagonists
- No specific antidote to calcium folinate overdose
Therapeutic Class
Supportive Care Therapy
Storage Conditions
Do not store above 30°C. Keep away from light and out of the reach of children