Hertin 440 mg/20 ml (IV Infusion)
440 mg vial: ৳ 100,000.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Trastuzumab |
| Company | Techno drugs ltd |
Title
Hertin Medicine
Categories
- Cancer Treatment:
- Breast Cancer
- Metastatic Breast Cancer
- Metastatic Gastric Cancer
- Pharmacology:
- HER2, c-erbB2 proto-oncogene
- Dosage:
- Adjuvant Treatment
- Metastatic Treatment
- Metastatic Gastric Cancer Treatment
- Administration:
- Sterile Syringe
- Reconstitution
- Storage Conditions
- Interaction:
- Anthracycline Interaction
- Side Effects:
- Cardiomyopathy
- Infusion Reactions
- Embryo-Fetal Toxicity
- Pulmonary Toxicity
- Exacerbation of Chemotherapy-Induced Neutropenia
- Pregnancy & Lactation:
- Fetal Harm Caution
- Contraception Recommendation
- Precautions & Warnings:
- Cardiac Monitoring
- Embryo-Fetal Toxicity
- Pulmonary Toxicity
- Exacerbation of Chemotherapy-Induced Neutropenia
- Use in Special Populations:
- Pediatric Use
- Reconstitution:
- Bacteriostatic Water for Injection (BWFI)
- Sterille Water for Injection (SWFI)
- Storage Conditions:
- Temperature Requirements
- Protection from Light
Description
- Adjuvant Breast Cancer: Indicated for adjuvant treatment of HER2 overexpressing node-positive or node-negative ER/PR negative or with one high-risk feature breast cancer
- Metastatic Breast Cancer: Indicated for first-line or subsequent treatment of HER2-overexpressing metastatic breast cancer
- Metastatic Gastric Cancer: Indicated for treatment of patients with HER2-overexpressing metastatic gastric or gastroesophageal junction adenocarcinoma
Pharmacology
- Action: Inhibition of proliferation of human tumor cells that overexpress HER2
- ADCC: Mediator of antibody-dependent cellular cytotoxicity
Dosage
- Recommended Doses and Schedules: Adjuvant and metastatic treatment specifics
- Metastatic Gastric Cancer: Initial and subsequent dosage information
Administration
- Preparation:
- Reconstitution Process
- Storage Guidelines
- Visual Inspection: Assessment for particulate matter and discoloration
- Usability: Single-use solution recommendation for specific conditions
Interaction
- Risk: Increased cardiac dysfunction risk with anthracycline use
Side Effects
- Adverse Reactions:
- Cardiomyopathy
- Infusion Reactions
- Embryo-Fetal Toxicity
- Pulmonary Toxicity
- Exacerbation of Chemotherapy-Induced Neutropenia
- Common Adverse Reactions:
- Fever
- Nausea
- Vomiting
- Diarrhea
- Infections
- Adverse Reactions in Patients:
- Infusion Reactions
- Neutropenia
- Anemia
- Myalgia
Pregnancy & Lactation
- Fetal Harm: Fetal harm warning and advice for females of reproductive potential
Precautions & Warnings
- Cardiomyopathy:
- Cardiac Dysfunction
- LVEF Monitoring
- Symptomatic Myocardial Dysfunction
- Infusion Reactions:
- Severity
- Intervention
- Continuation Consideration
- Embryo-Fetal Toxicity: Advice for females of reproductive potential
- Pulmonary Toxicity: Warns about serious and fatal pulmonary events
- Exacerbation of Chemotherapy-Induced Neutropenia: Higher incidences of neutropenia and febrile neutropenia
Use in Special Populations
- Pediatric Use: Lack of established safety and effectiveness
Reconstitution
- Bacteriostatic Water for Injection (BWFI): Use with benzyl alcohol preservative
- Sterille Water for Injection (SWFI): Alternative for patients with benzyl alcohol hypersensitivity
Storage Conditions
- Temperature: Storage temperature range
- Protection from Light: Protective measures for maintaining product integrity