Cisplatin 1 mg/ml (IV Infusion)
10 mg vial: ৳ 502.00
Medicine Details
Indications
- Metastatic Testicular Tumors
- Metastatic Ovarian Tumors
- Advanced Bladder Cancer
- Small Cell Lung Carcinoma
Pharmacology
- Platinum compound
- Inhibits DNA structure
- Inhibits DNA synthesis
- Inhibits protein synthesis
- Inhibits RNA synthesis
Dosage & Administration
- Administered by slow intravenous infusion
- Usual dose for testicular cancer
- Usual dose for metastatic ovarian tumors
- Usual dose for advanced bladder cancer
- Usual dose for non small cell lung carcinoma
Interaction
- Combined with antineoplastic drugs
- Nephrotoxic drugs interaction
- Ototoxic drugs interaction
- Renally excreted drugs interaction
- Anticonvulsant agents interaction
- Antigout agents interaction
Contraindications
- Pre-existing renal impairment
- History of hypersensitivity to Cisplatin
- History of hypersensitivity to Platinum containing compounds
- Myelosuppressed patients
- Patients with hearing impairment
Side Effects
- Severe nausea and vomiting
- Electrolyte disturbances
- Hypomagnesemia
- Hypocalcemia
- Hypokalemia
- Renal tubular dysfunction
Pregnancy & Lactation
- Pregnancy Category D
- Excretion in human milk
Precautions & Warnings
- Cumulative nephrotoxicity
- Renal function evaluation
- Serum electrolyte evaluation
- Peripheral blood count monitoring
- Hearing function evaluation
- Neurotoxicity evaluation
- Careful observation for anaphylactoid reactions
- Nausea and vomiting management
- Carcinogenicity risk
- Dental care
Overdose Effects
- Kidney failure
- Liver failure
- Deafness
- Ocular toxicity
- Myelosuppression
- Intractable nausea and vomiting
- Neuritis
- Death risk
- General supportive measures
Therapeutic Class
- Cytotoxic Chemotherapy
Storage Conditions
- Store at 25°C
- Do not refrigerate
- Protect from light
- Keep out of the reach of children