Apulset 8 mg/4 ml (IM/IV Injection)

4 ml ampoule: ৳ 30.00 (1 x 5: ৳ 150.00)

Medicine Details

Category Details
Generic Ondansetron
Company Aristopharma ltd
Also available as
Apulset 8 mg tablet Apulset 4 mg oral solution

Indications

  • Prevention of nausea and vomiting associated with emetogenic cancer chemotherapy
  • Prevention and treatment of post-operative nausea and vomiting
  • Prevention of radiotherapy-induced nausea and vomiting

Dosage

  • 8 mg tablet/orodispersible tablet
  • 4 mg orodispersible tablet
  • Injection
  • Chemotherapy-induced Nausea and Vomiting dosages for different age groups
  • Radiotherapy-induced Nausea and Vomiting dosages for different situations
  • Postoperative Nausea and Vomiting dosages for different age groups
  • Dosage for different types of cancer chemotherapy
  • Dosage for radiotherapy-induced Nausea and Vomiting
  • Dosage for postoperative Nausea and Vomiting

Mode of Action

  • 5HT3 receptor-antagonist
  • Precise mode of action unknown
  • Antagonism of 5HT3 receptors on neurons in peripheral and central nervous system

Administration

  • Step by step administration guide for Oral Soluble Film

Interaction

  • Metabolism by hepatic cytochrome P-450 drug-metabolizing enzymes
  • Influenced by inducers or inhibitors of cytochrome P-450 system

Contraindications

  • Hypersensitivity to the drug or any of its components
  • Concomitant use of apomorphine

Side Effects

  • Frequent adverse events like headache, constipation, diarrhea
  • Rash in chemotherapy-induced Nausea and Vomiting
  • Sensation of flushing, hiccups, liver enzyme abnormalities
  • Rare cases of anaphylaxis, brochospasm, tachycardia, angina, hypokalemia, shortness of breath
  • No evidence of extrapyramidal reactions

Pregnancy & Lactation

  • No evidence of impaired fertility or harm to fetus in animals
  • No adequate and well-controlled studies in pregnant women
  • Excretion in breast milk of rats, caution in nursing women

Precautions & Warnings

  • Reported hypersensitivity reactions
  • Not a drug that stimulates gastric or intestinal peristalsis
  • Should not be used instead of nasogastric suction
  • May mask a progressive ileus and/or gastric distension

Use in Special Populations

  • Dosage adjustment for patients with impaired renal function
  • Dosage adjustment for severe hepatic impairment
  • Limited information about pediatric patients 4 years of age or younger
  • No dosage adjustment for patients over the age of 65

Therapeutic Class

  • Anti-emetic drugs

Storage Conditions

  • Store at temperature not exceeding 30°C
  • Dry place
  • Protect from light and moisture

Related Brands