Apulset 8 mg/4 ml (IM/IV Injection)
4 ml ampoule: ৳ 30.00 (1 x 5: ৳ 150.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ondansetron |
| Company | Aristopharma ltd |
| Also available as |
Indications
- Prevention of nausea and vomiting associated with emetogenic cancer chemotherapy
- Prevention and treatment of post-operative nausea and vomiting
- Prevention of radiotherapy-induced nausea and vomiting
Dosage
- 8 mg tablet/orodispersible tablet
- 4 mg orodispersible tablet
- Injection
- Chemotherapy-induced Nausea and Vomiting dosages for different age groups
- Radiotherapy-induced Nausea and Vomiting dosages for different situations
- Postoperative Nausea and Vomiting dosages for different age groups
- Dosage for different types of cancer chemotherapy
- Dosage for radiotherapy-induced Nausea and Vomiting
- Dosage for postoperative Nausea and Vomiting
Mode of Action
- 5HT3 receptor-antagonist
- Precise mode of action unknown
- Antagonism of 5HT3 receptors on neurons in peripheral and central nervous system
Administration
- Step by step administration guide for Oral Soluble Film
Interaction
- Metabolism by hepatic cytochrome P-450 drug-metabolizing enzymes
- Influenced by inducers or inhibitors of cytochrome P-450 system
Contraindications
- Hypersensitivity to the drug or any of its components
- Concomitant use of apomorphine
Side Effects
- Frequent adverse events like headache, constipation, diarrhea
- Rash in chemotherapy-induced Nausea and Vomiting
- Sensation of flushing, hiccups, liver enzyme abnormalities
- Rare cases of anaphylaxis, brochospasm, tachycardia, angina, hypokalemia, shortness of breath
- No evidence of extrapyramidal reactions
Pregnancy & Lactation
- No evidence of impaired fertility or harm to fetus in animals
- No adequate and well-controlled studies in pregnant women
- Excretion in breast milk of rats, caution in nursing women
Precautions & Warnings
- Reported hypersensitivity reactions
- Not a drug that stimulates gastric or intestinal peristalsis
- Should not be used instead of nasogastric suction
- May mask a progressive ileus and/or gastric distension
Use in Special Populations
- Dosage adjustment for patients with impaired renal function
- Dosage adjustment for severe hepatic impairment
- Limited information about pediatric patients 4 years of age or younger
- No dosage adjustment for patients over the age of 65
Therapeutic Class
- Anti-emetic drugs
Storage Conditions
- Store at temperature not exceeding 30°C
- Dry place
- Protect from light and moisture