Apulset 8 mg (Tablet)
Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Ondansetron |
| Company | Aristopharma ltd |
| Also available as |
Indications and Uses
- Prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy
- Prevention and treatment of post-operative nausea and vomiting
- Prevention of radiotherapy-induced nausea and vomiting
Dosage Forms and Strengths
- 8 mg tablet/orodispersible tablet
- 4 mg orodispersible tablet
- Injection
- Ondansetron oral solution: 30 ml (24 mg), 10 ml (8 mg), 5 ml (4 mg)
Administration Method
Orally dissolving film designed to be applied on top of the tongue
Active Ingredient
Apulset base
Chemical Formula
C18H19N3O
Pharmacological Action
Selective blocking agent of the serotonin 5-HT3 receptor type
Mode of Action
Blocks initiation of vomiting reflex by antagonizing 5HT3 receptors
Interaction
Metabolized by hepatic cytochrome P-450 drug-metabolizing enzymes
Contraindications
Hypersensitivity to the drug or any of its components, concomitant use of apomorphine
Side Effects
- Headache
- Constipation
- Diarrhea
- Rash
- Flushing or warmth sensation
- Hiccups
- Liver enzyme abnormalities
- Anaphylaxis
- Brochospasm
- Tachycardia
- Angina
- Hypokalemia
- Shortness of breath
- No evidence of extrapyramidal reactions
Pregnancy & Lactation
- No evidence of impaired fertility or harm to the fetus in animal studies
- Excreted in the breast milk of rats, caution in nursing women
Precautions & Warnings
- Hypersensitivity reactions reported
- Not to be used as a stimulant for gastric or intestinal peristalsis
- Caution in patients following abdominal surgery or with chemotherapy-induced nausea and vomiting
Special Population
- Renal Function: Dosage recommendation same as for general population
- Hepatic Function: Single maximal daily dose of 8 mg recommended in severe hepatic impairment
- 4 years of age or younger: Little information available
- Over the age of 65: No dosage adjustment needed
Therapeutic Class
Anti-emetic drugs
Storage Conditions
Store at temperature not exceeding 30°C in a dry place, protect from light and moisture