Apulset 8 mg (Tablet)

Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)

Strip Price: ৳ 100.00

Medicine Details

Category	Details
Generic	Ondansetron
Company	Aristopharma ltd
Also available as	Apulset 8 mg injection Apulset 4 mg oral solution

Indications and Uses

Prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy
Prevention and treatment of post-operative nausea and vomiting
Prevention of radiotherapy-induced nausea and vomiting

Dosage Forms and Strengths

8 mg tablet/orodispersible tablet
4 mg orodispersible tablet
Injection
Ondansetron oral solution: 30 ml (24 mg), 10 ml (8 mg), 5 ml (4 mg)

Administration Method

Orally dissolving film designed to be applied on top of the tongue

Active Ingredient

Apulset base

Chemical Formula

C18H19N3O

Pharmacological Action

Selective blocking agent of the serotonin 5-HT3 receptor type

Mode of Action

Blocks initiation of vomiting reflex by antagonizing 5HT3 receptors

Interaction

Metabolized by hepatic cytochrome P-450 drug-metabolizing enzymes

Contraindications

Hypersensitivity to the drug or any of its components, concomitant use of apomorphine

Side Effects

Headache
Constipation
Diarrhea
Rash
Flushing or warmth sensation
Hiccups
Liver enzyme abnormalities
Anaphylaxis
Brochospasm
Tachycardia
Angina
Hypokalemia
Shortness of breath
No evidence of extrapyramidal reactions

Pregnancy & Lactation

No evidence of impaired fertility or harm to the fetus in animal studies
Excreted in the breast milk of rats, caution in nursing women

Precautions & Warnings

Hypersensitivity reactions reported
Not to be used as a stimulant for gastric or intestinal peristalsis
Caution in patients following abdominal surgery or with chemotherapy-induced nausea and vomiting

Special Population

Renal Function: Dosage recommendation same as for general population
Hepatic Function: Single maximal daily dose of 8 mg recommended in severe hepatic impairment
4 years of age or younger: Little information available
Over the age of 65: No dosage adjustment needed

Therapeutic Class

Anti-emetic drugs

Storage Conditions

Store at temperature not exceeding 30°C in a dry place, protect from light and moisture