Apulset 4 mg/5 ml (Oral Solution)
50 ml bottle: ৳ 45.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Ondansetron |
| Company | Aristopharma ltd |
| Also available as |
Title
- Apulset Oral Soluble Film
Categories
- Anti-emetic drugs
Indications
- Prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy
- Prevention and treatment of post-operative nausea and vomiting
- Prevention of radiotherapy-induced nausea and vomiting
Dosage
- Various dosages for adults, pediatric patients, and different types of chemotherapy and radiotherapy
- Oral solution and oral soluble film dosages provided
- Dosage adjustment for patients with impaired renal or hepatic function
Mode of Action
- Selective blocking agent of the serotonin 5-HT3 receptor type
- Mechanism of action in nausea and vomiting control
Pharmacology
- Ondansetron is a potent, highly selective 5HT3 receptor-antagonist
- Precise mode of action not fully known
- Effect in management of nausea and vomiting induced by cytotoxic chemotherapy and radiotherapy
Administration
- Instructions for administration of the oral soluble film
Interaction
- Information about drug-metabolizing enzyme system and clearance
Contraindications
- Hypersensitivity to the drug or any of its components
- Concomitant use of apomorphine
Side Effects
- Frequently reported adverse events such as headache, constipation, and diarrhea
- Occurrence of rash, sensation of flushing or warmth, hiccups, and liver enzyme abnormalities
- Rare cases of anaphylaxis, brochospasm, tachycardia, and hypokalemia
Pregnancy & Lactation
- Carcinogenic effects not seen in 2-year studies in rats and mice
- No evidence of impaired fertility or harm to the fetus
- Caution advised when administered to nursing women
Precautions & Warnings
- Reported hypersensitivity reactions in patients with hypersensitivity to other selective 5-HT3 receptor antagonists
- Not a drug that stimulates gastric or intestinal peristalsis
- Caution advised in patients following abdominal surgery or with chemotherapy-induced nausea and vomiting
Use in Special Populations
- Dosage adjustment for impaired renal and hepatic function
- Limited information available about dosage in pediatric patients 4 years of age or younger
Therapeutic Class
- Anti-emetic drugs
Storage Conditions
- Store at temperature not exceeding 30°C in a dry place
- Protection from light and moisture
Active Ingredient
- Apulset base, the racemic form of Apulset
Empirical Formula
- C18H19N3O
Molecular Weight
- 293.3
Color
- Not specified
Dimensions
- Not applicable
Materials
- Orally dissolving film
Technical Specifications
- Selective blocking agent of serotonin 5-HT3 receptor type
Design Elements
- Oral soluble film designed to be applied on top of the tongue
Usability Features
- Oral soluble film does not require water to aid dissolution or swallowing
- No need for water for dissolution or swallowing