Epirubicin Sandoz 2 mg/ml (IV Infusion)
10 mg vial: ৳ 800.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Epirubicin hydrochloride |
| Company | Sandoz a novartis division |
Indications
- Adjuvant therapy
- Axillary node tumor involvement
- Breast cancer
Pharmacology
- Anthracycline
- Cytotoxic properties
- Inhibits DNA and RNA synthesis
- DNA cleavage by topoisomerase II
- DNA helicase inhibition
- Cytotoxic free radicals
- Rapid distribution into tissues
- Metabolized by liver and other organs
- Biliary and urinary excretion
- Terminal elimination half-life
Dosage & Administration
- Intravenous infusion
- Repeated 3-4-week cycles
- Total dose given on day 1 or divided on days 1 and 8
- Recommended dose of 100-120 mg/m²
- CEF-120 regimen
- FEC-100 regimen
- Prophylactic antibiotic therapy
- Physician's direction
Interaction
- Concomitant use with cardioactive compounds
- Cimetidine interaction
- Additive toxicity with other cytotoxic drugs
- Interaction with Paclitaxel and Docetaxel
- Effects after previous radiation therapy
- Impact of hepatic function changes
Contraindications
- Hypersensitivity to Epirubicin
- Hypersensitivity to anthracyclines or anthracenediones
Side Effects
- Myelosuppression
- Cardiotoxicity
- Alopecia
- Hyperpyrexia
- Lethargy
- Amenorrhoea
- Nausea
- Vomiting
- Diarrhea
- Fever
- Rash
- Anorexia
- Reddish appearance of urine
Pregnancy & Lactation
- Pregnancy Category D
- No adequate studies in pregnant women
- Excretion in human milk
- Consideration for nursing mothers
Precautions & Warnings
- Refrigerated storage precautions
- Handling and disposal procedures
- Supervision of qualified physicians
- Recovery from acute toxicities before treatment
- Baseline assessment of blood counts and cardiac function
- Monitoring for myelosuppression and cardiotoxicity
- Supportive care for complications
Use in Special Populations
- Dosage adjustments based on toxicities
- Considerations for bone marrow dysfunction
- Recommendations for hepatic impairment
- Lower doses in renal impairment
- Lack of established safety in pediatric use
- Monitoring toxicity in elderly female patients
Overdose Effects
- Supportive treatment for recovery of toxicities
- Observation for signs of CHF
Therapeutic Class
- Cytotoxic Chemotherapy
Storage Conditions
- Store in refrigerator or at 2-8°C
- Protection from light
- Keep out of reach of children