Paclitaxel AqVida 6 mg/ml (IV Infusion)
30 mg vial: ৳ 2,012.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Paclitaxel |
| Company | Aqvida gmbh |
Indications
- Ovarian Carcinoma
- Breast Carcinoma
- Non-Small Cell Lung Carcinoma
- Kaposi's Sarcoma
- Gastric Carcinoma
Pharmacology
- Promotes assembly of microtubules
- Stabilizes microtubules
- Inhibition of cellular functions
- Induces abnormal microtubule arrays
Dosage & Administration
- Premedication necessary
- First-line treatment of ovarian cancer
- Second-line treatment of ovarian cancer
- Adjuvant chemotherapy in breast carcinoma
- First-line chemotherapy of breast carcinoma
- Second-line chemotherapy of breast carcinoma
- Advanced non-small-cell lung cancer treatment
- Treatment of AIDS-related KS
- Dose adjustment based on tolerance
Interaction
- Cimetidine does not affect clearance
- Interaction with cisplatin
- Interaction with doxorubicin
- Metabolism by cytochrome P450 isoenzymes
Contraindications
- Severe hypersensitivity reactions
- Contradicted during lactation
- Baseline neutrophils & platelets levels
- Severe hepatic impairment
- Serious uncontrolled infections
Side Effects
- Low blood counts
- Hair loss
- Peripheral neuropathy
- Nausea
- Vomiting
- Diarrhea
- Hypersensitivity reactions
- Fever
- Swelling of feet or ankles
- Liver problems
Pregnancy & Lactation
- Pregnancy Category D
- Contraindicated during lactation
Precautions & Warnings
- Administered under supervision of experienced physician
- Supportive equipment for hypersensitivity reactions
- Monitoring infusion site for possible infiltration
- Hypersensitivity reactions monitoring
- Bone marrow suppression monitoring
- Cardiac conduction abnormalities monitoring
Use in Special Populations
- Dose reduction for severe neutropenia
- Dose adjustment for hepatic impairment
- Not recommended for pediatric use
Overdose Effects
- No known antidote
- Close monitoring
- Treatment for primary anticipated toxicities
Reconstitution
- Must be diluted prior to infusion
- Dilution in specified solutions
- Physically and chemically stable for up to 27 hours
- Visual inspection prior to administration
Storage Conditions
- Store below 30°C
- Protect from light
- Keep out of reach of children
- Use only freshly prepared solution