Paclitaxel AqVida 6 mg/ml (IV Infusion)

30 mg vial: ৳ 2,012.00

Medicine Details

Category Details
Generic Paclitaxel
Company Aqvida gmbh

Indications

  • Ovarian Carcinoma
  • Breast Carcinoma
  • Non-Small Cell Lung Carcinoma
  • Kaposi's Sarcoma
  • Gastric Carcinoma

Pharmacology

  • Promotes assembly of microtubules
  • Stabilizes microtubules
  • Inhibition of cellular functions
  • Induces abnormal microtubule arrays

Dosage & Administration

  • Premedication necessary
  • First-line treatment of ovarian cancer
  • Second-line treatment of ovarian cancer
  • Adjuvant chemotherapy in breast carcinoma
  • First-line chemotherapy of breast carcinoma
  • Second-line chemotherapy of breast carcinoma
  • Advanced non-small-cell lung cancer treatment
  • Treatment of AIDS-related KS
  • Dose adjustment based on tolerance

Interaction

  • Cimetidine does not affect clearance
  • Interaction with cisplatin
  • Interaction with doxorubicin
  • Metabolism by cytochrome P450 isoenzymes

Contraindications

  • Severe hypersensitivity reactions
  • Contradicted during lactation
  • Baseline neutrophils & platelets levels
  • Severe hepatic impairment
  • Serious uncontrolled infections

Side Effects

  • Low blood counts
  • Hair loss
  • Peripheral neuropathy
  • Nausea
  • Vomiting
  • Diarrhea
  • Hypersensitivity reactions
  • Fever
  • Swelling of feet or ankles
  • Liver problems

Pregnancy & Lactation

  • Pregnancy Category D
  • Contraindicated during lactation

Precautions & Warnings

  • Administered under supervision of experienced physician
  • Supportive equipment for hypersensitivity reactions
  • Monitoring infusion site for possible infiltration
  • Hypersensitivity reactions monitoring
  • Bone marrow suppression monitoring
  • Cardiac conduction abnormalities monitoring

Use in Special Populations

  • Dose reduction for severe neutropenia
  • Dose adjustment for hepatic impairment
  • Not recommended for pediatric use

Overdose Effects

  • No known antidote
  • Close monitoring
  • Treatment for primary anticipated toxicities

Reconstitution

  • Must be diluted prior to infusion
  • Dilution in specified solutions
  • Physically and chemically stable for up to 27 hours
  • Visual inspection prior to administration

Storage Conditions

  • Store below 30°C
  • Protect from light
  • Keep out of reach of children
  • Use only freshly prepared solution

Related Brands