Fluracil 25 mg/ml (IV Injection or Infusion)
250 mg vial: ৳ 75.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Fluorouracil |
| Company | Drug international ltd |
Indications
- Carcinoma of the colon or rectum
- Carcinoma of the stomach and exocrine pancreas
- Carcinoma of the liver
- Carcinoma of the breast
- Carcinoma of the bladder
- Carcinoma of the lung
- Epithelial ovarian carcinoma
- Cervical carcinoma
Pharmacology
- Inactive as such in mammalian cells
- Converted into the active 5-fluorodeoxyuridine monophosphate (FdUMP)
- Inhibits the enzyme thymidylate kinase
- Forms stable complex with the folate cofactor N-5, 10-methylene tetrahydrofolate
- Incorporated into RNA
- Limited mainly to proliferative phase of cells
- Affects cells in G2 and S phase
Dosage & Administration
- Intravenous delivery by rapid bolus injection or slow infusion
- Common schedules for intravenous administration
- Palliative management dosing
- Dosing for poor-risk patients and those who are not in an adequate nutritional state
- Maintenance therapy dosing
- Usual adult dose for cervical cancer
- Usual pediatric dose for malignant disease
- Intra-arterial infusion dosing
- Combination with radiation dosing
- Combination with other anticancer drugs dosing
Interaction
- Pre-treatment with cimetidine led to increased plasma concentrations
Contraindications
- Severely debilitated patients
- Patients with bone marrow suppression
- Pregnant or breastfeeding women
- Patients without malignant illnesses
Side Effects
- Potentially life-threatening effects
- Cardiac effects
- Hematological effects
- Neurological effects
- Other effects
Pregnancy & Lactation
- Contraindicated throughout pregnancy
- Risk of teratogenesis
- Not known whether excreted in human milk
Precautions & Warnings
- Highly toxic drug
- Narrow margin of safety
- Signs of toxicity to prompt treatment discontinuation
Use in Special Populations
- Neonates
- Children
- The elderly
Overdose Effects
- Deliberate overdose cases unknown
- Excessive toxicity because of hematological effects
- No specific antidote
Reconstitution
- Cytotoxic anticancer drug
- Caution required in handling
- Special, trained personnel for reconstitution
- Restrictions on smoking, eating, and drinking in the preparation room
- Need for protective equipment
- Procedures for handling skin or mucous membrane exposure
- Pregnant women warning
- Proper disposal of waste
Storage Conditions
- Store in original carton not exceeding 25℃
- Do not refrigerate
- Protect from light