Drucil 25 mg/ml (IV Injection or Infusion)
Medicine Details
| Category | Details |
|---|---|
| Generic | Fluorouracil |
| Company | Healthcare pharmaceuticals ltd |
Indications
- Carcinoma of the colon or rectum
- Carcinoma of the stomach and exocrine pancreas
- Carcinoma of the liver
- Carcinoma of the breast
- Carcinoma of the bladder
- Carcinoma of the lung
- Epithelial ovarian carcinoma
- Cervical carcinoma
Pharmacology
5-fluorouracil is converted into the active 5-fluorodeoxyuridine monophosphate (FdUMP) by a variety of different metabolic pathways.
Dosage & Administration
Intravenous administration at specific doses and schedules for different types of cancer, including palliative management, poor risk patients, maintenance therapy, cervical cancer, and pediatric dose for malignant disease.
Interaction
Pre-treatment with cimetidine can lead to increased plasma concentrations of the drug.
Contraindications
Contraindicated in severely debilitated patients, those with bone marrow suppression, pregnant or breastfeeding women, and patients without malignant illnesses.
Side Effects
- Potentially life-threatening effects
- Cardiac effects
- Hematological effects
- Neurological effects
- Allergic reaction
- Decreased bone marrow function
- Hand-foot syndrome
- Severe vomiting, diarrhea, frequent bowel movements
- Mild to moderate nausea, vomiting
- Balance problems
- Confusion
- Rash and itching
- Temporary hair loss
- Conjunctivitis
Pregnancy & Lactation
Contraindicated throughout pregnancy, not known whether excreted in human milk.
Precautions & Warnings
Highly toxic drug, daily dose should not exceed 1 gram, treatment should be discontinued promptly when signs of toxicity appear.
Use in Special Populations
- Neonates
- Children
- The elderly
Overdose Effects
No specific antidote to overdose, treatment consists of supportive care.
Reconstitution
Special, trained personnel should reconstitute the drug, caution should be exercised in handling, pregnant women must avoid handling.
Storage Conditions
Store in original carton not exceeding 25℃, protect from light.