Soricap 10 mg (Capsule)

Unit Price: ৳ 45.00 (1 x 7: ৳ 315.00)

Strip Price: ৳ 315.00

Medicine Details

Category	Details
Generic	Acitretin
Company	Unimed unihealth pharmaceuticals ltd
Also available as	Soricap 25 mg capsule

Indications

Severe extensive psoriasis
Palmo-plantar pustular psoriasis
Severe congenital ichthyosis
Severe Darier’s disease

Pharmacology

Aromatic analogue of vitamin A
Regulation of RNA/DNA synthesis
Modulation of factors influencing epidermal proliferation
Modulation of the immune response

Dosage & Administration

Initial daily dose of 25mg or 30mg for 2 to 4 weeks
Daily dosage of 25-50mg for 6 to 8 weeks
Maximum dose of 75mg/day
Starting dose of 10mg for Darier’s disease patients
Daily dosage for children is about 0.5mg/kg

Interaction

Concurrent intake with ethanol leads to formation of etretinate
Contraindicated with methotrexate, tetracyclines, and other retinoids
Partially reduces protein binding of phenytoin
Low dose progesterone-only products may be inadequate contraception

Contraindications

Highly teratogenic - not for use by pregnant or breastfeeding women
Contraindicated in severe hepatic or renal impairment
Contraindicated in cases of hypersensitivity to the preparation
Not for patients with rare glucose-galactose malabsorption

Side Effects

Most patients experience dose-related adverse effects
Initial worsening of psoriasis symptoms may occur

Pregnancy & Lactation

Highly teratogenic
Contraindicated in pregnant women or nursing mothers

Precautions & Warnings

Exceptionally high risk of giving birth to a deformed child
Enhanced effects of UV light
Monitoring of hepatic function and serum cholesterol/triglycerides
Altered glucose tolerance
Possibility of alopecia
Decreased night vision may occur

Overdose Effects

Signs and symptoms similar to acute Vitamin A toxicity
Low acute toxicity

Therapeutic Class

Oral Retinoid preparations

Storage Conditions

Store in a cool & dry place
Protected from light
Do not store above 25°C

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