Peptonil-R 150 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ranitidine hydrochloride |
| Company | Decent pharma laboratories ltd |
Indications
- Treatment of active duodenal ulcer
- Benign gastric ulcer
- Treatment & prevention of ulcer associated with non-steroidal anti-inflammatory agent
- Post-operative stress ulcer
- Zollinger-Ellison Syndrome
- Gastroesophageal reflux disease (GERD)
- Gastro-intestinal hemorrhage from stress ulcer in seriously ill patient
- Recurrent hemorrhage in patients with bleeding peptic ulcer
- Before general anesthesia in patient considered to be at risk of acid aspiration particularly obstetric patients
Pharmacology
Competitively blocks histamine at H2-receptors of the gastric parietal cells which inhibits gastric acid secretion. Does not affect pepsin secretion, pentagastrin-stimulated intrinsic factor secretion or serum gastrin.
Dosage & Administration
- 150 mg twice daily for duodenal and gastric ulcer
- 150 mg twice daily for reflux oesophagitis
- 150 mg 3 times daily for Zollinger Ellison syndrome
- 150 mg twice daily for episodic dyspepsia
- 150 mg at night for maintenance
- 2-4 mg/kg twice daily for children with peptic ulcer
- IV injection or IV infusion for prophylaxis of haemorrhage from stress ulceration
Interaction
Delayed absorption and increased peak serum concentration with propantheline bromide. Minimally inhibits hepatic metabolism of coumarin anticoagulants, theophylline, diazepam and propanolol. May alter absorption of pH-dependent drugs and reduce bioavailability with antacids.
Contraindications
Hypersensitivity to Ranitidine
Side Effects
- Altered bowel habit
- Dizziness
- Rash
- Tiredness
- Reversible confusional states
- Headache
- Decreased blood counts
- Muscle or joint pain
Pregnancy & Lactation
- Ranitidine crosses the placenta
- Excreted in human breast milk
Precautions & Warnings
Should be given in reduced dosage to patients with impaired renal and hepatic function
Use in Special Populations
Ulcer healing rates have been found similar in elderly patients. No difference in the incidence of adverse effects.
Overdose Effects
No particular problems are expected following overdosage. Symptomatic and supportive therapy should be given as appropriate. Hemodialysis can be used if required.
Therapeutic Class
H2 receptor antagonist
Reconstitution
- Slow IV injection with specified diluents
- Intermittent slow IV infusion with specified diluents
- Continuous IV infusion with specified diluents
Storage Conditions
Store in a cool and dry place. Protect from light