Clovir 5% w/w (Cream)

Indications

• For the treatment of recurrent herpes labialis in adults and adolescents 12 years and older

Pharmacology

• Acyclovir is an antiviral drug active against herpes simplex virus
• Inhibits viral DNA replication through competitive inhibition, incorporation into viral DNA chain, and inactivation of viral DNA polymerase

Dosage & Administration

• Apply five times per day for four days
• Initiate therapy as early as possible
• Same dosage for adolescents 12 years and older

Interaction

• No identified interactions with topical or systemic administration of other drugs
• Unlikely systemic drug interactions due to minimal absorption

Contraindications

• Contraindicated in patients with known hypersensitivity to acyclovir, valacyclovir, or any component of the formulation

Side Effects

• Common adverse reactions at the application site include dry lips, desquamation, dryness of skin, burning skin, pruritus, flakiness of skin, and stinging
• Less than 1% occurrence in patients receiving the cream

Pregnancy & Lactation

• Pregnancy Category B
• Use during pregnancy only if potential benefit justifies potential risk to fetus
• Not known if topically applied acyclovir is excreted in breast milk
• Minimal systemic exposure following topical administration

Precautions & Warnings

• Only apply on the external aspects of the lips and face
• Avoid application to human mucous membranes
• Intended for cutaneous use only
• Potential for irritation and contact
• Not established in immunocompromised patients

Use in Special Populations

• Safety profile in 12 to 17-year-old patients similar to that in adults
• Safety and effectiveness not established in patients less than 12 years of age
• Limited data for patients aged 65 and over

Therapeutic Class

• Topical Antiviral preparations

Storage Conditions

• Store at room temperature between 20°C to 25°C

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