Ranison 50 mg/2 ml (IM/IV Injection)
2 ml ampoule: ৳ 10.03 (2 x 5: ৳ 100.30)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ranitidine hydrochloride |
| Company | Jayson pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of active duodenal ulcer
- Benign gastric ulcer
- Prevention of ulcer associated with non-steroidal anti-inflammatory agent
- Post operative stress ulcer
- Zollinger-Ellison Syndrome
- Gastroesophageal reflux disease (GERD)
- Gastro-intestinal haemorrhage from stress ulcer in seriously ill patient
- Recurrent haemorrhage in patients with bleeding peptic ulcer
- Before general anesthesia in patient
- Considered to be at risk of acid aspiration particularly obstetric patients
Pharmacology
- Competitively blocks histamine at H2-receptors
- Inhibits gastric acid secretion
- Does not affect pepsin secretion
- Does not affect pentagastrin-stimulated intrinsic factor secretion
- Does not affect serum gastrin
Dosage & Administration
- Usual dosage 150 mg twice daily
- Can be taken in the morning and evening
- Can be taken as a single daily dose at night
- Dosage for reflux oesophagitis
- Dosage for Zollinger Ellison syndrome
- Recommended dosage for prophylaxis
- Oral dose for children with peptic ulcer
- Intravenous injection dosage
- Intravenous infusion dosage
- Intramuscular injection dosage
- Dosage adjustments for children
Interaction
- Delayed absorption and increased peak serum concentration with propantheline bromide
- Minimally inhibits hepatic metabolism of certain drugs
- May alter absorption of pH-dependent drugs
- May reduce bioavailability with antacids
Contraindications
- Patients hypersensitive to Ranitidine
Side Effects
- Altered bowel habit
- Dizziness
- Rash
- Tiredness
- Reversible confusional states
- Headache
- Decreased blood counts
- Muscle or joint pain
Pregnancy & Lactation
- Ranitidine crosses the placenta
- No evidence of impaired fertility or harm to the fetus
- Caution during pregnancy
- Excreted in human breast milk
- Caution when administered to a nursing mother
Precautions & Warnings
- Reduced dosage for patients with impaired renal and hepatic function
Use in Special Populations
- Use in elderly patients
Overdose Effects
- No particular problems expected following overdosage with the drug
- Symptomatic and supportive therapy may be given
- Hemodialysis may be necessary
Therapeutic Class
- H2 receptor antagonist
Reconstitution
- Instructions for slow IV injection
- Instructions for intermittent slow IV infusion
- Instructions for continuous IV infusion
- Dilution guidelines for Zollinger-Ellison syndrome or other hypersecretory conditions
Storage Conditions
- Store in a cool and dry place
- Protect from light