Ranitid 300 mg (Tablet)
Unit Price: ৳ 4.02 (10 x 10: ৳ 401.84)
Strip Price: ৳ 40.18
Medicine Details
| Category | Details |
|---|---|
| Generic | Ranitidine hydrochloride |
| Company | Opsonin pharma ltd |
| Also available as |
Indications
- Treatment of active duodenal ulcer
- Benign gastric ulcer
- Ulcer associated with non-steroidal anti-inflammatory agent
- Post operative stress ulcer
- Zollinger-Ellison Syndrome
- Gastroesophageal reflux disease (GERD)
- Gastro-intestinal haemorrhage from stress ulcer
- Recurrent haemorrhage in patients with bleeding peptic ulcer
- Before general anesthesia in patient considered to be at risk of acid aspiration particularly obstetric patients
Pharmacology
- Competitively blocks histamine at H2-receptors of the gastric parietal cells
- Inhibits gastric acid secretion
- Does not affect pepsin secretion
- Does not affect pentagastrin-stimulated intrinsic factor secretion
- Does not affect serum gastrin
Dosage & Administration
- Usual dosage of 150 mg twice daily for duodenal and gastric ulcer
- 300 mg as a single daily dose at night for 4 to 8 weeks for duodenal and gastric ulcer
- 150 mg twice daily for reflux oesophagitis
- 300 mg at bedtime for reflux oesophagitis for up to 8 weeks
- 150 mg 3 times daily for Zollinger Ellison syndrome
- Increased dosage for Zollinger Ellison syndrome if necessary
- 150 mg twice daily or 300 mg at bedtime for episodic dyspepsia for up to 6 weeks
- 150 mg at night for preventing recurrences
- For children with peptic ulcer: 2-4 mg/kg twice daily, maximum 300 mg daily
Interaction
- Delayed absorption and increased peak serum concentration with propantheline bromide
- Minimal inhibition of hepatic metabolism of coumarin anticoagulants, theophylline, diazepam, and propanolol
- May alter absorption of pH-dependent drugs (e.g. ketoconazole, midazolam, glipizide)
- Reduction of bioavailability with antacids
Contraindications
- Hypersensitivity to Ranitidine
Side Effects
- Altered bowel habit
- Dizziness
- Rash
- Tiredness
- Reversible confusional states
- Headache
- Decreased blood counts
- Muscle or joint pain
Pregnancy & Lactation
- Ranitidine crosses the placenta
- No evidence of impaired fertility or harm to the foetus
- Caution during lactation
Precautions & Warnings
- Reduced dosage for patients with impaired renal and hepatic function
Use in Special Populations
- Similar ulcer healing rates in elderly patients
- No difference in adverse effects incidence between elderly and younger patients
Overdose Effects
- Specific action with no particular problems expected
- Symptomatic and supportive therapy recommended
Therapeutic Class
- H2 receptor antagonist
Reconstitution
- Specific reconstitution instructions for slow IV injection, intermittent slow IV infusion, and continuous IV infusion
- Different dilution instructions for patients with hypersecretory conditions
Storage Conditions
- Store in a cool and dry place
- Protect from light