Ranitid 50 mg/2 ml (IM/IV Injection)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ranitidine hydrochloride |
| Company | Opsonin pharma ltd |
| Also available as |
Indications
- Treatment of active duodenal ulcer
- Benign gastric ulcer
- Ulcer prevention with non-steroidal anti-inflammatory agents
- Post operative stress ulcer
- Zollinger-Ellison Syndrome
- Gastroesophageal reflux disease (GERD)
- Gastrointestinal hemorrhage in seriously ill patients
- Recurrent hemorrhage in patients with bleeding peptic ulcer
- Prevention of acid aspiration before general anesthesia
Pharmacology
Competitively blocks histamine at H2-receptors of the gastric parietal cells, inhibiting gastric acid secretion. Does not affect pepsin secretion, pentagastrin-stimulated intrinsic factor secretion, or serum gastrin.
Dosage & Administration
- Tablet & Syrup:
- Duodenal and gastric ulcer: 150 mg twice daily for 4 to 8 weeks
- Reflux oesophagitis: 150 mg twice daily for up to 8 weeks
- Zollinger Ellison syndrome: 150 mg 3 times daily, up to 6 g daily in divided doses
- Episodic dyspepsia: 150 mg twice daily for up to 6 weeks
- Maintenance: 150 mg at night for preventing recurrences
- Child (peptic ulcer): 2-4 mg/kg twice daily, maximum 300 mg daily
- IV injection & IV Infusion: Doses and administration methods for different indications and patient groups
Interaction
Delayed absorption and increased peak serum concentration with propantheline bromide. Minimal inhibition of hepatic metabolism of certain drugs. May alter absorption of pH-dependent drugs and reduce bioavailability with antacids.
Contraindications
Patients hypersensitive to Ranitidine
Side Effects
- Altered bowel habit
- Dizziness
- Rash
- Tiredness
- Reversible confusional states
- Headache
- Decreased blood counts
- Muscle or joint pain
Pregnancy & Lactation
- Pregnancy: Crosses placenta. No evidence of impaired fertility or harm to the fetus, but use only if essential.
- Lactation: Excreted in human breast milk. Caution advised when administered to a nursing mother.
Precautions & Warnings
Reduced dosage for patients with impaired renal and hepatic function.
Use in Special Populations
Similar ulcer healing rates in elderly patients as in younger patients, with no difference in adverse effects incidence.
Overdose Effects
No particular problems expected following overdosage with the drug. Symptomatic and supportive therapy recommended.
Therapeutic Class
H2 receptor antagonist
Reconstitution
Detailed reconstitution instructions for different modes of administration and patient groups.
Storage Conditions
Store in a cool and dry place, protect from light.