Rantec 300 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ranitidine hydrochloride |
| Company | Medimet pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of active duodenal ulcer
- Benign gastric ulcer
- Treatment & prevention of ulcer associated with non-steroidal anti-inflammatory agent
- Post operative stress ulcer
- Zollinger-Ellison Syndrome
- Gastroesophageal reflux disease (GERD)
- Gastro-intestinal haemorrhage from stress ulcer in seriously ill patient
- Recurrent haemorrhage in patients with bleeding peptic ulcer
- Before general anesthesia in patient considered to be at risk of acid aspiration particularly obstetric patients
Pharmacology
Competitively blocks histamine at H2-receptors of the gastric parietal cells which inhibits gastric acid secretion
Dosage & Administration
- 150 mg twice daily for duodenal and gastric ulcer
- 150 mg twice daily for reflux oesophagitis
- 150 mg 3 times daily for Zollinger Ellison syndrome
- 150 mg twice daily for episodic dyspepsia
- 150 mg at night for prevention of recurrences
- 2-4 mg/kg twice daily for children with peptic ulcer
- Ranitidine injection given intravenously as a slow or intermittent infusion for prophylaxis of haemorrhage from stress ulceration
- Ranitidine injection for prophylaxis of upper gastrointestinal haemorrhage in seriously ill patients or patients at risk of developing aspiration syndrome
Interaction
Delayed absorption and increased peak serum concentration with propantheline bromide. Minimally inhibits hepatic metabolism of coumarin anticoagulants, theophylline, diazepam, and propanolol. May alter absorption of pH-dependent drugs (e.g. ketoconazole, midazolam, glipizide). May reduce bioavailability with antacids
Contraindications
Patients hypersensitive to Ranitidine
Side Effects
- Altered bowel habit
- Dizziness
- Rash
- Tiredness
- Reversible confusional states
- Headache
- Decreased blood counts
- Muscle or joint pain
Pregnancy & Lactation
- Pregnancy: Ranitidine crosses the placenta. No evidence of impaired fertility or harm to the fetus. Should only be used if considered essential
- Lactation: Excreted in human breast milk. Caution should be exercised when administered to a nursing mother
Precautions & Warnings
Should be given in reduced dosage to patients with impaired renal and hepatic function
Use in Special Populations
Ulcer healing rates found similar in patients age 65 and over with those in younger patients. No difference in the incidence of adverse effects
Overdose Effects
No particular problems are expected following overdosage. Symptomatic and supportive therapy should be given as appropriate
Therapeutic Class
H2 receptor antagonist
Reconstitution
- Rantec 50 mg diluted to a concentration ≤2.5 mg/mL for slow IV inj or ≤0.5 mg/mL for intermittent slow IV infusion
- Rantec 150 mg diluted in 250 mL for continuous IV infusion
- Patients with Zollinger-Ellison syndrome or other hypersecretory conditions: Rantec should be diluted to a concentration ≤2.5 mg/mL
Storage Conditions
Store in a cool and dry place. Protect from light