Ranul 150 mg (Tablet)
Unit Price: ৳ 2.00 (10 x 10: ৳ 200.00)
Strip Price: ৳ 20.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Ranitidine hydrochloride |
| Company | Apex pharmaceuticals ltd |
Product Title
- Ranul
Categories
- Medicine
- Pharmaceutical
Description
- Ranul is indicated for the treatment of active duodenal ulcer, benign gastric ulcer, treatment and prevention of ulcer associated with non-steroidal anti-inflammatory agent, post-operative stress ulcer, Zollinger-Ellison Syndrome, gastroesophageal reflux disease (GERD), and more.
- It competitively blocks histamine at H2-receptors of the gastric parietal cells, inhibiting gastric acid secretion, without affecting pepsin secretion, pentagastrin-stimulated intrinsic factor secretion, or serum gastrin.
- Dosage and administration for tablets, syrup, IV injection, and IV infusion are based on the condition being treated, such as duodenal and gastric ulcer, reflux esophagitis, Zollinger-Ellison syndrome, episodic dyspepsia, and maintenance.
- Interactions include delayed absorption and increased peak serum concentration with propantheline bromide, minimal inhibition of hepatic metabolism of certain drugs, and alteration of absorption of pH-dependent drugs.
- Contraindicated in patients hypersensitive to Ranitidine.
- Side effects are usually uncommon and may include altered bowel habit, dizziness, rash, tiredness, reversible confusional states, headache, decreased blood counts, and muscle or joint pain.
- Caution advised during pregnancy and lactation due to crossing the placenta and excretion in breast milk, respectively.
- Precautions in reduced dosage for patients with impaired renal and hepatic function, and use in elderly patients.
- No specific problems expected following overdosage with the drug; symptomatic and supportive therapy should be given as appropriate.
- Belongs to the therapeutic class of H2 receptor antagonist.
- Reconstitution details for Slow IV inj, intermittent slow IV infusion, continuous IV infusion, and for patients with specific conditions.
- Store in a cool and dry place, protected from light.
Dosage and Administration
- 150 mg twice daily for 4 to 8 weeks for duodenal and gastric ulcer
- 150 mg twice daily for reflux esophagitis
- 150 mg 3 times daily for Zollinger Ellison syndrome
- 150 mg twice daily for episodic dyspepsia
- 150 mg at night for maintenance
- For children with peptic ulcer: 2-4 mg/kg twice daily, maximum 300 mg daily
- IV injection may be given slowly or as intermittent IV infusion; dosage based on specific conditions; safety and effectiveness not established in case of children.
Interactions
- Delayed absorption and increased peak serum concentration with propantheline bromide
- Minimal inhibition of hepatic metabolism of coumarin anticoagulants, theophylline, diazepam, and propranolol
- May alter absorption of pH-dependent drugs (e.g. ketoconazole, midazolam, glipizide)
- May reduce bioavailability with antacids
Contraindications
- Patients hypersensitive to Ranitidine
Side Effects
- Altered bowel habit
- Dizziness
- Rash
- Tiredness
- Reversible confusional states
- Headache
- Decreased blood counts
- Muscle or joint pain
Pregnancy & Lactation
- Ranitidine crosses the placenta with no evidence of impaired fertility or harm to the fetus; use during pregnancy should be considered essential
- Excreted in human breast milk; caution advised during lactation
Precautions & Warnings
- Reduced dosage for patients with impaired renal and hepatic function
- Use in elderly patients
Overdose Effects
- Specific problems not expected following overdosage with the drug
- Symptomatic and supportive therapy recommended
- Haemodialysis if required
Therapeutic Class
- H2 receptor antagonist
Reconstitution
- Details for reconstitution for Slow IV inj, intermittent slow IV infusion, continuous IV infusion, and for patients with specific conditions
Storage Conditions
- Store in a cool and dry place
- Protect from light