Renete 150 mg (Tablet)

Unit Price: ৳ 2.50 (15 x 10: ৳ 375.00)
Strip Price: ৳ 25.00

Medicine Details

Category Details
Generic Ranitidine hydrochloride
Company Euro pharma ltd

Indications

  • Treatment of active duodenal ulcer
  • Benign gastric ulcer
  • Treatment & prevention of ulcer associated with non-steroidal anti-inflammatory agent
  • Post operative stress ulcer.
  • Zollinger-Ellison Syndrome.
  • Gastroesophageal reflux disease (GERD).
  • Gastro-intestinal haemorrhage from stress ulcer in seriously ill patient.
  • Recurrent haemorrhage in patients with bleeding peptic ulcer.
  • Before general anesthesia in patient considered to be at risk of acid aspiration particularly obstetric patients.

Pharmacology

Ranitidine competitively blocks histamine at H2-receptors of the gastric parietal cells which inhibits gastric acid secretion. It does not affect pepsin secretion, pentagastrin-stimulated intrinsic factor secretion, or serum gastrin.

Dosage & Administration

  • 150 mg twice daily taken in the morning and evening or 300 mg as a single daily dose at night for 4 to 8 weeks for duodenal and gastric ulcer.
  • 150 mg twice daily or 300 mg at bedtime for up to 8 weeks for reflux oesophagitis.
  • 150 mg 3 times daily and increased if necessary up to 6 g daily in divided doses for Zollinger Ellison syndrome.
  • 150 mg twice daily or 300 mg at bedtime for up to 6 weeks for episodic dyspepsia.
  • 150 mg at night for preventing recurrences for maintenance.
  • 2-4 mg/kg twice daily, maximum 300 mg daily for children with peptic ulcer. Ranitidine injection may be given either as a slow intravenous injection, intermittent intravenous infusion, or intramuscular injection based on different conditions.

Interaction

Delayed absorption and increased peak serum concentration with propantheline bromide. Renete minimally inhibits hepatic metabolism of coumarin anticoagulants, theophylline, diazepam, and propanolol. May alter absorption of pH-dependent drugs (e.g. ketoconazole, midazolam, glipizide). May reduce bioavailability with antacids.

Contraindications

Patients hypersensitive to Ranitidine

Side Effects

  • Altered bowel habit
  • Dizziness
  • Rash
  • Tiredness
  • Reversible confusional states
  • Headache
  • Decreased blood counts
  • Muscle or joint pain are side effects which are usually uncommon.

Pregnancy & Lactation

Ranitidine crosses the placenta. There is no evidence of impaired fertility or harm to the fetus due to Ranitidine. Caution should be exercised when the drug is administered to a nursing mother.

Precautions & Warnings

Renete should be given in reduced dosage to patients with impaired renal and hepatic function.

Use in Special Populations

In clinical trials, the ulcer healing rates have been found similar in patients age 65 and over with those in younger patients. Additionally, there was no difference in the incidence of adverse effects.

Overdose Effects

Renete is very specific in action and accordingly no particular problems are expected following overdosage with the drug. Symptomatic and supportive therapy should be given as appropriate. If required, the drug may be removed from the plasma by haemodialysis.

Therapeutic Class

H2 receptor antagonist

Reconstitution

  • Renete 50 mg diluted to a concentration ≤2.5 mg/mL for slow IV injection, Renete 50 mg diluted to a concentration ≤0.5 mg/mL for intermittent slow IV infusion, Renete 150 mg diluted in 250 mL of dextrose 5% injection or NaCl 0.9%, lactated Ringer's, Na bicarbonate 5% solution for continuous IV infusion. Renete should be diluted to a concentration ≤2.5 mg/mL with dextrose 5% or NaCl 0.9%, lactated Ringer's, Na bicarbonate 5% solution for patients with Zollinger-Ellison syndrome or other hypersecretory conditions.

Storage Conditions

Store in a cool and dry place. Protect from light.

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