Duoblock 5 mg+40 mg (Tablet)
Unit Price: ৳ 21.00 (3 x 10: ৳ 630.00)
Strip Price: ৳ 210.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Amlodipine besilate olmesartan medoxomil |
| Company | Aristopharma ltd |
| Also available as |
Indications
- Treatment of hypertension alone or with other antihypertensive agents
- Lowering blood pressure
- Initial therapy for patients likely to need multiple antihypertensive agents
Pharmacology
- Amlodipine as a dihydropyridine calcium channel blocker
- Amlodipine's greater effect on vascular smooth muscle cells than on cardiac muscle cells
- Olmesartan Medoxomil blocking of vasoconstrictor and aldosterone-secreting effects of angiotensin II
Dosage & Administration
- Initial therapy with 5/20 mg dosage
- Titration up to a maximum of 10/40 mg once daily
- Lower recommended starting dose of Amlodipine in elderly patients
Interaction
- Potential attenuation of antihypertensive effect by NSAIDs including selective COX-2 inhibitors
Contraindications
- Cannot be co-administered with Aliskiren in patients with diabetes
Side Effects
- Peripheral edema
- Headache
- Flushing
- Dizziness
- Sprue-like enteropathy
Pregnancy & Lactation
- Pregnancy Category D
- Avoid use in 2nd and 3rd trimester
- Discontinuation when pregnancy is detected
- Unknown excretion in human milk
- Potential adverse effects on nursing infants
Precautions & Warnings
- Risk of hypotension in volume- or salt-depleted patients
- Risk of vasodilation in patients with severe aortic stenosis
- Risk of increased frequency, duration, or severity of angina or acute MI in patients with severe obstructive coronary artery disease
Use in Special Populations
- Lack of established safety and effectiveness in pediatric patients
- No overall differences in safety or effectiveness observed in subjects 65 years of age or older
- No studies in patients with renal impairment
- Initial therapy not recommended in hepatically impaired patients
Overdose Effects
- No information on overdose in humans
Therapeutic Class
- Combined antihypertensive preparations
Storage Conditions
- Do not store above 30°C
- Keep away from light
- Keep out of the reach of children