Apoxyclav (125 mg+31.25 mg)/5 ml (Powder for Suspension)
100 ml bottle: ৳ 150.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Amoxicillin clavulanic acid |
| Company | Apex pharmaceuticals ltd |
Indications
- Short-term treatment of bacterial infections
- Upper respiratory tract infections
- Lower respiratory tract infections
- Genito-urinary tract infections
- Skin and soft tissue infections
- Bone and joint infections
- Other infections
Composition
- 375 mg tablet: Amoxicillin 250 mg, Clavulanic Acid 125 mg
- 625 mg tablet: Amoxicillin 500 mg, Clavulanic Acid 125 mg
- 1 gm tablet: Amoxicillin 875 mg, Clavulanic Acid 125 mg
- Powder for Suspension: Amoxicillin 125 mg, Clavulanic Acid 31.25 mg
- Powder for Suspension (Forte): Amoxicillin 400 mg, Clavulanic Acid 57.5 mg
- 1.2 gm Injection: Amoxicillin 1 gm, Clavulanate Potassium 200 mg
- 0.6 gm injection: Amoxicillin 500 mg, Clavulanate Potassium 100 mg
Pharmacology
- Broad spectrum of bactericidal activity
- Effective against Gram-positive & Gram-negative microorganisms
- Inactivation of beta-lactamase enzymes
- Optimized absorption at the start of a meal
- Low levels of serum binding
Dosage
- Varied dosages for different age groups
- Different dosages for different types and severity of infections
- Oral and intravenous administration
- Duration of treatment not to exceed 14 days without review
Administration
- Enhanced absorption when taken at the start of a meal
- Intravenous injection over 2 minutes
- Slow intravenous infusion over 30 minutes
- Reconstituted vial to be used within 20 minutes
Interaction
- Prolongation of bleeding time and prothrombin time
- Reduction in efficacy of oral contraceptives
- Potential interaction with allopurinol
Contraindications
- History of Penicillin hypersensitivity
- Possible cross-sensitivity with other beta-lactam antibiotics
Side Effects
- Mild and transitory nature for most side effects
- Possible gastrointestinal side effects
- Rare reports of hepatitis and cholestatic jaundice
- Rare occurrence of skin reactions
Pregnancy & Lactation
- No teratogenic effect observed in animal studies
- Limited use in human pregnancy with no untoward effect
- Trace quantities detected in breast milk during lactation
Precautions & Warnings
- Use with care in patients on anticoagulation therapy
- Dosage adjustment for patients with renal or hepatic impairment
- Maintenance of adequate fluid intake and urinary output
Use in Special Populations
- Dosage adjustment for patients with renal impairment
- Monitor hepatic function at regular intervals
Overdose Effects
- Unlikely occurrence of overdose
- Gastrointestinal symptoms and fluid/electrolyte imbalances may occur
Therapeutic Class
- Broad spectrum penicillins
Reconstitution
- Reconstitution of IV injection with water for injection
- Avoid mixing with specific fluids
- Injection into infusion fluids containing glucose, bicarbonate, and dextran over 3-4 minutes
Storage Conditions
- Storage below 25°C, protected from light and moisture
- Reconstituted suspension to be refrigerated and used within 7 days
- Reconstituted vial to be used within 20 minutes