Augment 500 mg+125 mg (Tablet)
Unit Price: ৳ 32.00 (3 x 6: ৳ 576.00)
Strip Price: ৳ 192.00
Medicine Details
Category | Details |
---|---|
Generic | Amoxicillin clavulanic acid |
Company | Eskayef pharmaceuticals ltd |
Also available as |
Indications
- Short-term treatment of bacterial infections
- Upper respiratory tract infections (tonsillitis, sinusitis, otitis media)
- Lower respiratory tract infections (acute and chronic bronchitis, lobar and bronchopneumonia)
- Genito-urinary tract infections (cystitis, urethritis, pyelonephritis)
- Skin and soft tissue infections
- Bone and joint infections (osteomyelitis)
- Other infections (septic abortion, puerperal sepsis, intra-abdominal sepsis etc.)
Composition
- 375 mg tablet
- 625 mg tablet
- 1 gm tablet
- Powder for Suspension
- Powder for Suspension (Forte)
- 1.2 gm Injection
- 0.6 gm injection
- Amoxicillin 250 mg as Amoxicillin Trihydrate BP
- Amoxicillin 500 mg as Amoxicillin Trihydrate BP
- Amoxicillin 875 mg as Amoxicillin Trihydrate BP
- Clavulanic Acid 125 mg as Diluted Potassium Clavulanate BP
- Clavulanic Acid 31.25 mg as Diluted Potassium Clavulanate BP
- Clavulanic Acid 57.5 mg as Diluted Potassium Clavulanate BP
- Clavulanic Acid 200 mg as Clavulanate Potassium USP
- Clavulanic Acid 100 mg as Clavulanate Potassium USP
Pharmacology
- Antibacterial combination of Amoxicillin and Clavulanic Acid
- Broad spectrum of bactericidal activity
- Inactivation of beta-lactamase enzymes
- Peak serum levels occur about one hour after oral administration
- Optimized absorption at the start of a meal
Dosage
- Adults and children over 12 years
- Tablet dosage for different infections severity
- Suspension dosage for different age groups
- Forte suspension dosage for mild to moderate infections
- IV Injection dosage for adults and children
Administration
- Oral dosage form
- IV injection administration
- Enhanced absorption when administered at the start of a meal
- Intravenous injection over 2 minutes
Interaction
- Prolongation of bleeding time and prothrombin time
- Reduction of oral contraceptives efficacy
- Concomitant use of allopurinol
- No data on concomitant use of Co-amoxiclav and allopurinol
Contraindications
- History of Penicillin hypersensitivity
- Possible cross-sensitivity with other beta-lactam antibiotics
- Patients with a previous history of Co-amoxiclav or Penicillin-associated cholestatic jaundice
Side Effects
- Uncommon and of mild and transitory nature
- Gastrointestinal side effects may be reduced by taking at the start of meals
- Rare cases of hepatitis, cholestatic jaundice, urticarial and erythematous rashes
- Potential occurrence of angioedema and anaphylaxis
Pregnancy & Lactation
- No teratogenic effect in animal studies
- Limited use in human pregnancy with no untoward effect
- Not recommended in pregnancy unless considered essential
- Trace quantities detected in breast milk during lactation
Precautions & Warnings
- Use with care in patients on anticoagulation therapy or with severe hepatic dysfunction
- Dosage adjustment in moderate or severe renal impairment
- Importance of maintaining adequate fluid intake and urinary output
Use in Special Populations
- Dose adjustment in patients with renal impairment
- Dose adjustment in hepatic impairment
Overdose Effects
- Unlikely occurrence of overdose problems
- Possible gastrointestinal symptoms and disturbance of fluid and electrolyte balances
- Removal from circulation by haemodialysis if necessary
Therapeutic Class
- Broad spectrum penicillins
Reconstitution
- IV injection reconstitution in Water for Injection BP
- Not suitable for reconstitution or mixing with certain fluids
- Injection into drip tubing of infusion fluids
Storage Conditions
- Should be stored below 25°C, protected from light and moisture
- Reconstituted suspension stored in the refrigerator (not frozen) and used within 7 days
- Reconstituted vial must be used within 20 minutes
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