Augment 875 mg+125 mg (Tablet)

Unit Price: ৳ 40.00 (2 x 6: ৳ 480.00)
Strip Price: ৳ 240.00

Medicine Details

Category Details
Generic Amoxicillin clavulanic acid
Company Eskayef pharmaceuticals ltd
Also available as
Augment 250 mg tablet Augment 500 mg tablet Augment 125 mg suspension Augment 1 gm injection

Indications

  • Treatment of upper respiratory tract infections
  • Treatment of lower respiratory tract infections
  • Treatment of genito-urinary tract infections
  • Treatment of skin and soft tissue infections
  • Treatment of bone and joint infections
  • Treatment of other infections

Composition

  • 375 mg tablet: Amoxicillin 250 mg as Amoxicillin Trihydrate BP and Clavulanic Acid 125 mg as Diluted Potassium Clavulanate BP
  • 625 mg tablet: Amoxicillin 500 mg as Amoxicillin Trihydrate BP and Clavulanic Acid 125 mg as Diluted Potassium Clavulanate BP
  • 1 gm tablet: Amoxicillin 875 mg as Amoxicillin Trihydrate BP and Clavulanic Acid 125 mg Diluted Potassium Clavulanate BP
  • Powder for Suspension: Amoxicillin 125 mg as Amoxicillin Trihydrate BP and Clavulanic Acid 31.25 mg as Diluted Potassium Clavulanate BP
  • Powder for Suspension (Forte): Amoxicillin 400 mg as Amoxicillin Trihydrate BP and Clavulanic Acid 57.5 mg as Diluted Potassium Clavulanate BP
  • 1.2 gm Injection: Amoxicillin Sodium BP (equivalent to Amoxicillin 1 gm) and Clavulanate Potassium USP (equivalent to Clavulanic Acid 200 mg)
  • 0.6 gm injection: Amoxicillin Sodium BP (equivalent to Amoxicillin 500) and Clavulanate Potassium USP (equivalent to Clavulanic Acid 100 mg)

Pharmacology

  • Pharmacodynamic properties: Antibacterial combination of Amoxicillin and Clavulanic Acid
  • Pharmacokinetic properties: Closely matched pharmacokinetics of Amoxicillin and Clavulanate, peak serum levels occur about one hour after oral administration

Dosage

  • Adults and children over 12 years:
    • Usual adult dose for different infections
    • Dosage for children based on age and weight

Administration

Oral dosage form can be taken without regard to meals, IV injection for intravenous administration

Interaction

  • Prolongation of bleeding time and prothrombin time
  • Potential reduction in efficacy of oral contraceptives
  • Potential increase in allergic skin reactions when used with allopurinol

Contraindications

  • History of Penicillin hypersensitivity
  • Cross-sensitivity with other beta-lactam antibiotics
  • Previous history of Co-amoxiclav or Penicillin-associated cholestatic jaundice

Side Effects

  • Uncommon and mild side effects such as diarrhea, indigestion, nausea, vomiting
  • Rare but serious side effects like hepatitis, cholestatic jaundice, skin reactions, angioedema, and anaphylaxis

Pregnancy & Lactation

  • Animal studies show no teratogenic effect
  • Limited use in human pregnancy with no untoward effect
  • Trace quantities detected in breast milk during lactation

Precautions & Warnings

  • Use with caution in patients on anticoagulation therapy or with severe hepatic dysfunction
  • Dosage adjustment in moderate or severe renal impairment
  • Maintain adequate fluid intake and urinary output during high dose administration

Use in Special Populations

  • Dose adjustment for patients with renal impairment
  • Special precautions for hepatic impairment

Overdose Effects

Unlikely to occur, may cause gastrointestinal symptoms and electrolyte imbalances

Therapeutic Class

Broad spectrum penicillins

Reconstitution

IV injection reconstituted with Water for Injection BP, not suitable for certain intravenous mixtures

Storage Conditions

Store below 25°C, protect from light and moisture, refrigerate reconstituted suspension, use within specified timeframe

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