Ultraclav 500 mg+125 mg (Tablet)
Unit Price: ৳ 28.75 (3 x 6: ৳ 517.50)
Strip Price: ৳ 172.50
Medicine Details
| Category | Details |
|---|---|
| Generic | Amoxicillin clavulanic acid |
| Company | Globe pharmaceuticals ltd |
Indications
- Upper respiratory tract infections (e.g. tonsillitis, sinusitis, otitis media)
- Lower respiratory tract infections (e.g. acute and chronic bronchitis, lobar and bronchopneumonia)
- Genito-urinary tract infections (e.g. cystitis, urethritis, pyelonephritis)
- Skin and soft tissue infections
- Bone and joint infections (e.g. osteomyelitis)
- Other infections (e.g. septic abortion, puerperal sepsis, intra-abdominal sepsis)
Composition
- 375 mg tablet
- 625 mg tablet
- 1 gm tablet
- Powder for Suspension
- Powder for Suspension (Forte)
- 1.2 gm Injection
- 0.6 gm injection
Pharmacology
- Bactericidal activity against many Gram-positive & Gram-negative microorganisms
- Broad spectrum of activity
- Resistance to degradation by (3-lactamases
- Ability to inactivate a wide range of beta-lactamase enzymes
Dosage
- Different dosages for adults and children
- Varied doses for different types of infections
- Recommended dosage for mild to moderate infections
- Higher dosage for serious infections
- Dosage adjustment for renal impairment
Administration
- Oral dosage form can be taken without regard to meals
- Enhanced absorption when taken at the start of a meal
- IV injection suitable for intravenous administration only
- Guidelines for IV injection administration
Interaction
- Prolongation of bleeding time and prothrombin time
- Reduction of efficacy of oral contraceptives
- Possible interaction with allopurinol
Contraindications
- History of Penicillin hypersensitivity
- Cross-sensitivity with other beta-lactam antibiotics
- Contraindicated for patients with previous history of Co-amoxiclav or Penicillin-associated cholestatic jaundice
Side Effects
- Uncommon and mainly of a mild and transitory nature
- Gastrointestinal side effects can be reduced by taking with meals
- Rare cases of hepatitis, cholestatic jaundice, and allergic skin reactions
- Reports of angioedema and anaphylaxis
Pregnancy & Lactation
- No teratogenic effects in animal studies
- Limited use in human pregnancy
- Trace quantities detected in breast milk during lactation
Precautions & Warnings
- Use with care in patients on anticoagulation therapy
- Dosage adjustment in patients with severe hepatic dysfunction
- Adjustment of dosage for patients with renal impairment
- Maintenance of adequate fluid intake and urinary output during high dose administration
Use in Special Populations
- Dosage adjustment for patients with renal impairment
- Monitoring of hepatic function at regular intervals
Overdose Effects
- Unlikely to occur
- Gastrointestinal symptoms and fluid/electrolyte disturbances if encountered
- Potential removal by haemodialysis
Therapeutic Class
Broad spectrum penicillins
Reconstitution
- Reconstitution process for IV injection
- Incompatibility with certain solutions for IV administration
- Guidelines for reconstituted solution administration
Storage Conditions
- Storage temperature below 25°C
- Protection from light and moisture
- Refrigeration of reconstituted suspension
- Time limitations for reconstituted vial