Wintack 150 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ranitidine hydrochloride |
| Company | The white horse pharmaceuticals ltd |
Indications
- Treatment of active duodenal ulcer
- Benign gastric ulcer
- Treatment & prevention of ulcer associated with non-steroidal anti-inflammatory agent
- Post operative stress ulcer
- Zollinger-Ellison Syndrome
- Gastroesophageal reflux disease (GERD)
- Gastro-intestinal haemorrhage from stress ulcer in seriously ill patient
- Recurrent haemorrhage in patients with bleeding peptic ulcer
- Before general anesthesia in patient considered to be at risk of acid aspiration particularly obstetric patients
Pharmacology
Ranitidine competitively blocks histamine at H2-receptors of the gastric parietal cells which inhibits gastric acid secretion. It does not affect pepsin secretion, pentagastrin-stimulated intrinsic factor secretion or serum gastrin.
Dosage & Administration
Usual dosage is 150 mg twice daily taken in the morning and evening or 300 mg as a single daily dose at night for 4 to 8 weeks. For children, the recommended oral dose for the treatment of peptic ulcer is 2 mg/kg to 4 mg/kg twice daily to a maximum of 300 mg ranitidine per day.
Interaction
Delayed absorption and increased peak serum concentration with propantheline bromide. Wintack minimally inhibits hepatic metabolism of coumarin anticoagulants, theophylline, diazepam and propanolol. May alter absorption of pH-dependent drugs (e.g. ketoconazole, midazolam, glipizide). May reduce bioavailability with antacids.
Contraindications
Patients hypersensitive to Ranitidine
Side Effects
- Altered bowel habit
- Dizziness
- Rash
- Tiredness
- Reversible confusional states
- Headache
- Decreased blood counts
- Muscle or joint pain
Pregnancy & Lactation
- Ranitidine crosses the placenta
- Excreted in human breast milk
- Caution should be exercised when administered to a nursing mother
Precautions & Warnings
Should be given in reduced dosage to patients with impaired renal and hepatic function
Use in Special Populations
Ulcer healing rates have been found similar in elderly patients
Overdose Effects
No particular problems expected following overdosage with the drug. Symptomatic and supportive therapy should be given as appropriate
Therapeutic Class
H2 receptor antagonist
Reconstitution
- Slow IV inj
- Intermittent slow IV infusion
- Continuous IV infusion for specific conditions
Storage Conditions
Store in a cool and dry place. Protect from light