Zenidine 150 mg (Tablet)
Unit Price: ৳ 2.00 (10 x 10: ৳ 200.00)
Strip Price: ৳ 20.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Ranitidine hydrochloride |
| Company | Zenith pharmaceuticals ltd |
Indications
- Treatment of active duodenal ulcer
- Benign gastric ulcer
- Treatment & prevention of ulcer associated with non-steroidal anti-inflammatory agent
- Post operative stress ulcer
- Zollinger-Ellison Syndrome
- Gastroesophageal reflux disease (GERD)
- Gastro-intestinal haemorrhage from stress ulcer in seriously ill patient
- Recurrent haemorrhage in patients with bleeding peptic ulcer
- Before general anesthesia in patient considered to be at risk of acid aspiration particularly obstetric patients
Pharmacology
Ranitidine competitively blocks histamine at H2-receptors of the gastric parietal cells which inhibits gastric acid secretion. It does not affect pepsin secretion, pentagastrin-stimulated intrinsic factor secretion or serum gastrin.
Dosage & Administration
- 150 mg twice daily taken in the morning and evening or 300 mg as a single daily dose at night for 4 to 8 weeks for duodenal and gastric ulcer
- 150 mg twice daily or 300 mg at bedtime for up to 8 weeks for reflux oesophagitis
- 150 mg 3 times daily and increased if necessary up to 6 g daily in divided doses for Zollinger Ellison syndrome
- 150 mg twice daily or 300 mg at bedtime for up to 6 weeks for episodic dyspepsia
- 150 mg at night for preventing recurrences for maintenance
- 2-4 mg/kg twice daily, maximum 300 mg daily for peptic ulcer in children
- Ranitidine injection may be given either as a slow (over a period of at least two minutes) intravenous injection of 50 mg, after dilution to a volume of 20 ml per 50 mg dose, which may be repeated every six to eight hours
- Ranitidine should be given in reduced dosage to patients with impaired renal and hepatic function
Interaction
- Delayed absorption and increased peak serum concentration with propantheline bromide
- Minimally inhibits hepatic metabolism of coumarin anticoagulants, theophylline, diazepam and propanolol
- May alter absorption of pH-dependent drugs (e.g. ketoconazole, midazolam, glipizide)
- May reduce bioavailability with antacids
Contraindications
Patients hypersensitive to Ranitidine
Side Effects
- Altered bowel habit
- Dizziness
- Rash
- Tiredness
- Reversible confusional states
- Headache
- Decreased blood counts
- Muscle or joint pain
Pregnancy & Lactation
- Ranitidine crosses the placenta
- No evidence of impaired fertility or harm to the foetus due to Ranitidine
- Ranitidine is excreted in human breast milk
- Caution should be exercised when the drug is administered to a nursing mother
Precautions & Warnings
Zenidine should be given in reduced dosage to patients with impaired renal and hepatic function
Use in Special Populations
- Ulcer healing rates have been found similar in patients age 65 and over with those in younger patients
- No difference in the incidence of adverse effects in elderly patients
Overdose Effects
Zenidine is very specific in action and accordingly no particular problems are expected following overdosage with the drug. Symptomatic and supportive therapy should be given as appropriate. If required, the drug may be removed from the plasma by haemodialysis
Therapeutic Class
H2 receptor antagonist
Reconstitution
- Zenidine 50 mg diluted to a concentration ≤2.5 mg/mL (e.g. total of 20 mL) with NaCl 0.9% inj or dextrose 5% or 10%, lactated Ringer's, Na bicarbonate 5% solution for slow IV inj
- Zenidine 50 mg diluted to a concentration ≤0.5 mg/mL (e.g. total of 100 mL) of dextrose 5% inj or NaCl 0.9%, lactated Ringer's, Na bicarbonate 5% solution for intermittent slow IV infusion
- Zenidine 150 mg diluted in 250 mL of dextrose 5% inj or NaCl 0.9%, lactated Ringer's, Na bicarbonate 5% solution for continuous IV infusion
Storage Conditions
Store in a cool and dry place. Protect from light.