Zodin 75 mg/5 ml (Syrup)
100 ml bottle: ৳ 40.15
Medicine Details
| Category | Details |
|---|---|
| Generic | Ranitidine hydrochloride |
| Company | Somatec pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of active duodenal ulcer
- Benign gastric ulcer
- Treatment & prevention of ulcer associated with non-steroidal anti-inflammatory agent
- Post operative stress ulcer
- Zollinger-Ellison Syndrome
- Gastroesophageal reflux disease (GERD)
- Gastro-intestinal haemorrhage from stress ulcer in seriously ill patient
- Recurrent haemorrhage in patients with bleeding peptic ulcer
- Before general anesthesia in patient considered to be at risk of acid aspiration particulary obstetric patients
Pharmacology
- Competitively blocks histamine at H2-receptors of the gastric parietal cells
- Inhibits gastric acid secretion
- Does not affect pepsin secretion
- Pentagastrin-stimulated intrinsic factor secretion
- Serum gastrin
Dosage & Administration
- Usual dosage of 150 mg twice daily for 4 to 8 weeks
- 300 mg as a single daily dose at night for 4 to 8 weeks
- 150 mg twice daily for reflux oesophagitis for up to 8 weeks
- 150 mg 3 times daily for Zollinger Ellison syndrome
- 150 mg twice daily for episodic dyspepsia for up to 6 weeks
- 150 mg at night for maintenance to prevent recurrences
- 2-4 mg/kg twice daily for children with peptic ulcer
- Ranitidine injection may be administered intravenously or intramuscularly at specified doses and intervals
Interactions
- Delayed absorption and increased peak serum concentration with propantheline bromide
- Minimally inhibits hepatic metabolism of coumarin anticoagulants, theophylline, diazepam and propanolol
- May alter absorption of pH-dependent drugs
- May reduce bioavailability with antacids
Contraindications
- Hypersensitivity to Ranitidine
Side Effects
- Altered bowel habit
- Dizziness
- Rash
- Tiredness
- Reversible confusional states
- Headache
- Decreased blood counts
- Muscle or joint pain
Pregnancy & Lactation
- Ranitidine crosses the placenta
- No evidence of impaired fertility or harm to the fetus
- Caution during lactation
Precautions & Warnings
- Reduced dosage for patients with impaired renal and hepatic function
Use in Special Populations
- Similar ulcer healing rates in elderly patients as in younger patients
- No difference in the incidence of adverse effects between elderly and younger patients
Overdose Effects
- Specific in action
- Symptomatic and supportive therapy recommended
Therapeutic Class
- H2 receptor antagonist
Reconstitution
- Specific dilution requirements for slow IV injection, intermittent slow IV infusion, and continuous IV infusion
- Additional dilution requirements for patients with specific conditions
Storage Conditions
- Store in a cool and dry place
- Protect from light