Iminem (250 mg+250 mg)/vial (IV Injection)

Unit Price: ৳ 650.00

Medicine Details

Category Details
Generic Imipenem cilastatin
Company Aci limited
Also available as
Iminem 500 mg injection

Indications

  • Lower respiratory tract infections
  • Urinary tract infections
  • Intra-abdominal infections
  • Gynecologic infections
  • Bacterial septicemia
  • Bone and joint infections
  • Skin and skin structure infections
  • Endocarditis

Pharmacology

  • Combination of Imipenem and Cilastatin
  • Imipenem is a penem antibacterial drug
  • Cilastatin sodium is a renal dehydropeptidase inhibitor
  • Bactericidal activity resulting from the inhibition of cell wall synthesis
  • High stability in the presence of beta-lactamases

Dosage & Administration - Adult Patients

  • Dosage based on suspected or confirmed pathogen susceptibility
  • Recommended dosage regimens for normal renal function
  • Reduction in dose for patients with decreased renal function

Dosage & Administration - Pediatric Patients

  • Dosage for pediatric patients for non-CNS infections
  • Doses less than or equal to 500 mg should be given by intravenous infusion over 20 to 30 minutes

Interaction

  • Concurrent administration with probenecid may increase the half-life of cilastatin
  • Increased risk of generalized seizures when used concurrently with ganciclovir

Contraindications

  • Hypersensitivity to any component of this combination

Side Effects

  • Phlebitis
  • Nausea, diarrhea, vomiting
  • Rash, pruritus, urticaria
  • Pain at injection site, erythema at injection site, vein induration
  • Fever
  • Hypotension
  • Seizures, dizziness, somnolence

Pregnancy & Lactation

  • Pregnancy Category C
  • Use during pregnancy if potential benefit justifies potential risk
  • Caution should be exercised when administered to a nursing woman

Precautions & Warnings

  • Serious and occasionally fatal hypersensitivity reactions reported in patients receiving therapy with beta-lactams
  • Seizures and other CNS adverse reactions reported during treatment with Imipenem

Therapeutic Class

  • Other beta-lactam Antibiotics

Reconstitution

  • Reconstitution and Preparation of Imipenem Solution for Intravenous Administration
  • Do not use diluents containing benzyl alcohol for neonates
  • Reconstituted solutions range from colorless to yellow
  • Reconstituted suspension must not be administered by direct intravenous infusion
  • Storage of reconstituted solutions for 4 hours at room temperature or for 24 hours under refrigeration

Storage Conditions

  • Store at or below 25°C temperature
  • Keep away from light and wet place
  • Keep out of reach of children

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