Zilsart 40 mg (Tablet)
Unit Price: ৳ 12.00 (3 x 10: ৳ 360.00)
Strip Price: ৳ 120.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Azilsartan medoxomil |
| Company | Acme laboratories ltd |
Indications
- Treatment of hypertension
- Lowering blood pressure
- Reducing risk of cardiovascular events
- Primary prevention of stroke and myocardial infarction
- Monotherapy or combination therapy
Pharmacology
- Inhibition of angiotensin II binding
- Vasoconstrictor and aldosterone-secreting effects
- Cardiac stimulation
- Renal reabsorption of sodium
- Selective blocking of AT1 receptor
- Independence from angiotensin II synthesis pathway
- Increased plasma renin activity
- Plasma aldosterone concentrations
- No effect on serum potassium or sodium
- Hydrolysis to active metabolite
- Dose-related inhibition of angiotensin II infusion pressor effects
- Plasma concentrations and activity levels after administration
- Absorption and bioavailability
- Peak plasma concentrations and time to reach peak level
- Protein binding and distribution
- Metabolism to primary metabolites
- Contribution to pharmacologic activity
- Metabolism by CYP2C9
Dosage & Administration
- Recommended dose in adults
- Dose adjustment for patients on high diuretic doses
- Additional blood pressure reduction with other antihypertensive agents
Interaction
- No observed interactions with specified drugs
- Potential attenuation by non-steroidal anti-inflammatory drugs
- Increased risks with dual blockade of the RAS
Contraindications
- Co-administration contraindicated with Aliskiren in diabetic patients
Side Effects
- Common adverse reaction: diarrhea
- Other side effects: nausea, asthenia, fatigue, muscle spasm, dizziness, cough
Pregnancy & Lactation
- Pregnancy Category D
- Increased fetal risk during second and third trimesters
- Unknown excretion in human milk
- Recommendation to consider discontinuation of nursing
Precautions & Warnings
- Reduced fetal renal function and increased morbidity
- Symptomatic hypotension in intravascularly volume-depleted patients
- Changes in renal function and potential renal failure
- Safety and effectiveness in pediatric patients
- No dose adjustment in elderly patients
- Likelihood of abnormally high serum creatinine values in elderly patients
- No dose adjustment in renal or hepatic impairment
Use in Special Populations
- Neonatal exposure effects
- Support for blood pressure and renal function in neonates
- No established safety and effectiveness in pediatric patients
- No dose adjustment in elderly patients
- Higher likelihood of high serum creatinine values in elderly
- No dose adjustment in renal impairment
- Higher reporting of high serum creatinine values in moderate to severe renal impairment
- No dose adjustment in mild or moderate hepatic impairment
- No study in severe hepatic impairment
Overdose Effects
- Limited data on human overdose
- Supportive therapy for overdose
- Non-dialyzable nature of the product
Therapeutic Class
- Angiotensin-II receptor blocker
Storage Conditions
- Storage in dry place
- Protection from light and heat
- Keep out of reach of children