Cosec 20 mg (Capsule (Enteric Coated))
Unit Price: ৳ 5.05 (5 x 10: ৳ 252.50)
Strip Price: ৳ 50.50
Medicine Details
Category | Details |
---|---|
Generic | Omeprazole |
Company | Drug international ltd |
Also available as |
Indications
- Gastric and duodenal ulcer
- NSAID-associated duodenal and gastric ulcer
- As prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
- Gastro-esophageal reflux disease
- Long-term management of acid reflux disease
- Acid-related dyspepsia
- Severe ulcerating reflux esophagitis
- Prophylaxis of acid aspiration during general anesthesia
- Zollinger-Ellison syndrome
- Helicobacter pylori-induced peptic ulcer
Pharmacology
- Inhibitor of gastric acid secretion
- Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
- Onset of antisecretory effect within one hour
- Maximum effect within two hours
- Inhibition of secretion lasts up to 72 hours
- Secretory activity returns gradually over 3 to 5 days after discontinuation
Dosage
- Dosage for benign gastric and duodenal ulcer
- Dosage for NSAID-associated duodenal or gastric ulcer
- Dosage for gastro-esophageal reflux disease
- Dosage for long-term management of acid reflux disease
- Dosage for acid-related dyspepsia
- Dosage for prophylaxis of acid aspiration
- Dosage for Zollinger-Ellison syndrome
- Dosage for Helicobacter pylori eradication regimen in peptic ulcer disease
- Paediatric use in severe ulcerating reflux esophagitis
- IV injection dosage for various purposes
Administration
- Direction for use of IV Injection
- Direction for use of IV Infusion
- Reconstitution of IV injection solution
- Intravenous administration instructions
- Preparation of IV infusion
Interaction
- Effect on absorption of ketoconazole
- Metabolism through cytochrome P450
- Effect on elimination of diazepam, phenytoin, and warfarin
- Monitoring of patients receiving warfarin or phenytoin
- Plasma concentrations during concomitant administration
- Absorption not affected by alcohol or food
- No evidence of interaction with specific medications
Contraindications
- Known hypersensitivity to omeprazole
- Exclusion of malignancy before treatment
Side Effects
- Mild and reversible adverse reactions
- Skin rash, urticaria, and pruritus
- Photosensitivity, bullous eruption, and erythema multiforme
- Diarrhoea, headache, constipation, nausea/vomiting, flatulence, and abdominal pain
- Dry mouth, stomatitis, and candidiasis
- Paraesthesia, dizziness, and feeling faint
- Somnolence, insomnia, and vertigo
- Reversible mental confusion, agitation, depression, and hallucinations
- Arthritic and myalgic symptoms
- Other rare reactions
Pregnancy & Lactation
- No adverse effects on pregnancy or fetus/newborn child
- Use during pregnancy
- No information available on passage into breast milk
- Discontinuation of breastfeeding if essential use
Precautions & Warnings
- Avoid concomitant use of clopidogrel
- Increased risk for osteoporosis-related fractures
- Atrophic gastritis in long-term use
- Concomitant use with methotrexate may lead to toxicities
Therapeutic Class
- Proton Pump Inhibitor
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children