Flexibac 5 mg/5 ml (Oral Solution)
100 ml bottle: ৳ 100.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Baclofen |
| Company | Beacon pharmaceuticals plc |
| Also available as |
Indications
- spasticity resulting from multiple sclerosis
- flexor spasms and concomitant pain
- clonus and muscular rigidity
- skeletal muscle spasm resulting from rheumatic disorders
- spinal cord injuries and other spinal cord diseases
- cerebrovascular accidents or neoplastic or degenerative brain disease
Pharmacology
- inhibits monosynaptic and polysynaptic reflexes at the spinal level
- stimulates the GABAB receptors
- inhibits release of glutamate and aspartate
- exerts antinociceptive effect
- produces CNS depression
Dosage & Administration
- 5 mg 3 times daily for adults & children over 10 years
- gradually increased; max. 100 mg daily
- initial treatment with 2.5 mg for children under 10 years
- increased according to requirement based on age
- maintenance doses for different age groups
Interaction
- increased sedation when taken with CNS agents, alcohol, or synthetic opiates
- potentiation effects with tricyclic antidepressants
- reports of mental confusion, hallucinations, headaches, and nausea with concomitant use of Parkinson's medication
- increased CNS depressant effects when used with MAO inhibitors
- caution when used with magnesium sulfate or other neuromuscular blocking agents
Contraindications
- hypersensitivity to any component of the product
Side Effects
- transient drowsiness
- daytime sedation
- dizziness
- weakness
- fatigue
- various central nervous system effects
- hypotension
- gastrointestinal effects
- genitourinary effects
- rash
- pruritus
- ankle edema
- excessive perspiration
- weight gain
- visual disturbances
- hepatic function disorders
- paradoxical increase in spasticity
Pregnancy & Lactation
- Pregnancy category B3
- crosses placental barrier
- use only when benefits outweigh hazards
- excreted in breast milk
- evidence suggests minimal effect on infants
Precautions & Warnings
- lower doses for impaired renal function
- caution for patients with psychotic disorders, schizophrenia, depressive or manic disorders
- appropriate supervision for patients with epilepsy and muscle spasticity
- caution in patients with peptic ulcers, cerebrovascular diseases, hepatic, renal, or respiratory failure
- monitoring of respiratory and cardiovascular function needed
- improvement in neurogenic disturbances affecting bladder emptying
- poor tolerance in stroke patients
- appropriate laboratory tests for hepatic diseases or diabetes mellitus
Overdose Effects
- gastric lavage in case of severe overdose
Therapeutic Class
- Centrally acting Skeletal Muscle Relaxants
Storage Conditions
- Keep below 30°C temperature
- away from light & moisture
- keep out of the reach of children