Spaflex 10 mg (Tablet)
Unit Price: ৳ 8.00 (3 x 10: ৳ 240.00)
Strip Price: ৳ 80.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Baclofen |
| Company | Nuvista pharma ltd |
| Also available as |
Title
- Spaflex
Categories
- Medicine
- Skeletal Muscle Relaxants
- Pharmacological Agents
Description
- Spasticity treatment for multiple sclerosis
- Treatment for flexor spasms and muscle rigidity
- Indicated for spinal cord injuries and diseases
- Contraindicated for patients with hypersensitivity to any component
Dosage and Administration
- 5 mg 3 times daily for adults and children over 10 years
- Gradually increased dosage up to 100 mg daily
- Varied dosage for children under 10 years based on age
Pharmacology
- Baclofen inhibits monosynaptic and polysynaptic reflexes at the spinal level
- Stimulates GABA receptors
- Antinociceptive effect
Interaction
- Increased sedation when taken with CNS agents, alcohol, or synthetic opiates
- Potential for increased hypotension when combined with antihypertensives
- Potentiation of effects with tricyclic antidepressants
- Reports of mental confusion and hallucinations when used with levodopa and carbidopa
- CNS depressant effects when used with MAO inhibitors
- Caution with neuromuscular blocking agents to avoid synergistic effects
Side Effects
- Transient drowsiness
- Daytime sedation
- Dizziness
- Weakness
- Fatigue
- Headache, insomnia, euphoria, depression, confusion, hallucinations, tremor, blurred vision, respiratory depression
- Hypotension, dyspnea, chest pain, syncope
- Nausea, constipation, dry mouth, abdominal pain, vomiting, diarrhea
- Urinary frequency, enuresis, urinary retention, impotence, nocturia
- Rash, pruritus, weight gain, hepatic function disorders
Pregnancy and Lactation
- Category B3
- Use during pregnancy only if benefits outweigh risks
- Excretion in breast milk with minimal effect on the infant
Precautions and Warnings
- Lower doses for patients with impaired renal function or undergoing chronic hemodialysis
- Cautious use for patients with psychotic disorders, schizophrenia, or manic disorders
- Seizure risk for patients with epilepsy
- Caution for patients with peptic ulcers, cerebrovascular diseases, or hepatic, renal, or respiratory failure
- Respiratory and cardiovascular function monitoring essential
Overdose Effects
- Gastric lavage for severe overdose
Therapeutic Class
- Centrally acting Skeletal Muscle Relaxants
Storage Conditions
- Keep below 30°C temperature
- Keep away from light and moisture
- Keep out of the reach of children