Beklo 5 mg/5 ml (Oral Solution)
Medicine Details
| Category | Details |
|---|---|
| Generic | Baclofen |
| Company | Opsonin pharma ltd |
| Also available as |
Indications
- spasticity resulting from multiple sclerosis
- flexor spasms and concomitant pain, clonus and muscular rigidity
- skeletal muscle spasm resulting from rheumatic disorders
- spinal cord injuries and other spinal cord diseases
- cerebrovascular accidents or neoplastic or degenerative brain disease
Pharmacology
Baclofen inhibits both monosynaptic and polysynaptic reflexes at the spinal level by stimulating the GABA B receptors, which inhibits the release of glutamate and aspartate. It may also act at intraspinal sites producing CNS depression. Baclofen also exerts an antinociceptive effect.
Dosage & Administration
Adult & children over 10 years: 5 mg 3 times daily, preferably with or after food, gradually increased; max. 100 mg daily. Children <10 years: Treatment is usually started with 2.5 mg (2.5 ml) given 4 times daily then raised according to requirement. Daily maintenance dose- 12 month-2 years: 10-20 mg (10-20 ml), 2 years-6 years: 20-30 mg (20-30 ml), 6 years-10 years: 30-60 mg (30-60 ml)
Interaction
- Increased sedation with CNS depressants
- Increased fall in blood pressure with antihypertensives
- Potentiated effects with tricyclic antidepressants
- Potential effects with Parkinson's medication
- CNS depressant effects with MAO inhibitors
- Synergistic effect with magnesium sulphate or other neuromuscular blocking agents
Contraindications
Baclofen is contraindicated in patients with hypersensitivity to any component of this product.
Side Effects
- Transient drowsiness
- Daytime sedation
- Dizziness
- Weakness
- Fatigue
- Headache
- Insomnia
- Euphoria
- Confusion
- Tremor
- Hypotension
- Nausea
- Constipation
- Urinary frequency
- Rash
- Ankle edema
- Excessive perspiration
- Weight gain
- Visual disturbances
Pregnancy & Lactation
Pregnancy category B3. Safe use of Baclofen during pregnancy has not been established. Baclofen crosses the placental barrier. Baclofen should only be administered to pregnant women when in the judgement of the physician concludes that the potential benefits outweigh the possible hazards. Baclofen is excreted in breast milk however evidence to date suggests that the quantities are so small that no undesirable effects on the infant would be expected.
Precautions & Warnings
- Lower doses for patients with impaired renal function
- Close monitoring for patients with psychotic disorders
- Appropriate supervision in patients with epilepsy
- Caution for patients with peptic ulcers, cerebrovascular diseases, or hepatic, renal or respiratory failure
- Careful monitoring of respiratory and cardiovascular function
- Caution in patients with preexisting sphincter hypertonia
- Limited benefit in stroke patients
Overdose Effects
Gastric lavage is important in case of severe overdose.
Therapeutic Class
Centrally acting Skeletal Muscle Relaxants
Storage Conditions
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.