Emez 20 mg (Capsule (Enteric Coated))
Unit Price: ৳ 5.00 (60's pack: ৳ 300.00)
Medicine Details
Category | Details |
---|---|
Generic | Omeprazole |
Company | Edruc limited |
Also available as |
Indications
- Treatment of gastric and duodenal ulcer
- NSAID-associated duodenal and gastric ulcer treatment
- Prophylaxis in patients with history of NSAID-associated duodenal and gastric ulcer
- Gastro-esophageal reflux disease treatment
- Long-term management of acid reflux disease
- Treatment of acid-related dyspepsia
- Severe ulcerating reflux esophagitis treatment
- Prophylaxis of acid aspiration during general anesthesia
- Zollinger-Ellison syndrome treatment
- Helicobacter pylori-induced peptic ulcer treatment
Pharmacology
- Inhibitor of gastric acid secretion
- Blocker of H+/K+ ATPase enzyme system
- Onset of antisecretory effect within one hour
- Maximum effect within two hours
- Inhibition of secretion lasts up to 72 hours
- Gradual return of secretory activity over 3 to 5 days after discontinuation
Dosage
- Oral administration for various conditions
- Maintenance doses for recurrent duodenal ulcer
- IV injection dosages for different conditions
- Pediatric dosage based on body weight
- Dosage for H. pylori eradication regimen
Administration
- IV injection directions
- IV infusion directions
- Preparation of IV injection
- Preparation of IV infusion
- Time limits for use after reconstitution
Interaction
- Decreased intragastric acidity affecting ketoconazole absorption
- Metabolism through cytochrome P450 affecting diazepam, phenytoin, and warfarin
- Absence of interaction with phenytoin in continuous treatment
- Absence of interaction with warfarin in continuous treatment
- Increased plasma concentrations during concomitant administration
- Useful interaction during H. pylori eradication
- Absence of interaction with certain drugs, alcohol, or food
- Interaction with digoxin leading to increased bioavailability
Contraindications
- Known hypersensitivity to omeprazole
- Exclusion of malignancy before treatment in suspected gastric ulcer
Side Effects
- Mild and reversible adverse reactions
- Skin rash, urticaria, and pruritus
- Photosensitivity, bullous eruption, erythema multiforme, angioedema, and alopecia
- Gastrointestinal reactions such as diarrhea, headache, constipation, nausea/vomiting, flatulence, and abdominal pain
- Other reactions including dry mouth, stomatitis, candidiasis, paraesthesia, dizziness, light headedness, and feeling faint
Pregnancy & Lactation
- No adverse effects on pregnancy or health of fetus/newborn child (based on studies)
- Use of omeprazole during pregnancy
- No information available on passage into breast milk or effects on neonate
- Discontinuation of breastfeeding if essential use of omeprazole is considered
Precautions & Warnings
- Avoid concomitant use of clopidogrel and omeprazole
- Possible association of PPI therapy with increased risk for osteoporosis-related fractures
- Occasional atrophic gastritis in long-term treatment
- Potential for methotrexate toxicity with concomitant use of PPIs
Therapeutic Class
- Proton Pump Inhibitor
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children
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