Eupi 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 5.00 (10 x 10: ৳ 500.00)
Strip Price: ৳ 50.00

Medicine Details

Category Details
Generic Omeprazole
Company Pharmasia limited
Also available as
Eupi 40 mg injection Eupi 40 mg capsule

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • As prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of the antisecretory effect occurs within one hour
  • Maximum effect occurring within two hours
  • Inhibition of secretion lasts up to 72 hours
  • After discontinuation, secretory activity returns gradually over 3 to 5 days

Dosage

  • Dosage for benign gastric and duodenal ulcer: 20 mg once daily for 4 weeks in duodenal ulceration, 8 weeks in gastric ulceration
  • Maintenance dose for recurrent duodenal ulcer: 20 mg once daily
  • Dosage for NSAID-associated duodenal or gastric ulcer: 20 mg once daily for 4 weeks, continued for further 4 weeks if not fully healed
  • Dosage for gastro-esophageal reflux disease: 20 mg once daily for 4 weeks, continued for further 4-8 weeks if not fully healed

Administration

  • Intravenous administration only for Omeprazole IV injection
  • Omeprazole IV infusion should be given as an intravenous infusion over a period of 20-30 minutes or more

Interaction

  • Reduced absorption of ketoconazole during Eupi treatment
  • Delay in the elimination of diazepam, phenytoin, and warfarin
  • Monitoring of patients receiving warfarin or phenytoin is recommended
  • Concomitant treatment with Eupi and clarithromycin results in increased plasma concentrations
  • No evidence of interaction with phenacetin, theophylline, caffeine, propranolol, metoprolol, cyclosporin, lidocaine, quinidine, estradiol, amoxycillin, or antacids

Contraindications

  • Known hypersensitivity to Omeprazole
  • Possibility of malignancy in suspected gastric ulcer

Side Effects

  • Skin rash, urticaria, and pruritus have been reported
  • Diarrhoea and headache have been reported
  • Other gastrointestinal reactions include constipation, nausea/vomiting, flatulence, and abdominal pain
  • Dizziness, light headedness, and feeling faint have been associated with treatment
  • Reversible mental confusion, agitation, depression, and hallucinations have occurred predominantly in severely ill patients

Pregnancy & Lactation

  • Results from three prospective epidemiological studies indicate no adverse effects of Omeprazole on pregnancy or on the health of the fetus/newborn child
  • Omeprazole can be used during pregnancy

Precautions & Warnings

  • Avoid concomitant use of clopidogrel and Eupi
  • Observational studies suggest that PPI therapy may be associated with an increased risk for osteoporosis-related fractures

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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