HK 20 mg (Capsule (Enteric Coated))
Unit Price: ৳ 5.00 (100's pack: ৳ 500.00)
Medicine Details
Category | Details |
---|---|
Generic | Omeprazole |
Company | Apollo pharmaceutical ltd |
Indications
- Treatment of gastric and duodenal ulcer
- Treatment of NSAID-associated duodenal and gastric ulcer
- Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
- Treatment of gastro-esophageal reflux disease
- Long-term management of acid reflux disease
- Treatment of acid-related dyspepsia
- Treatment of severe ulcerating reflux esophagitis
- Prophylaxis of acid aspiration during general anesthesia
- Treatment of Zollinger-Ellison syndrome
- Treatment of Helicobacter pylori-induced peptic ulcer
Pharmacology
- Omeprazole is an inhibitor of gastric acid secretion
- Blocks hydrogen-potassium-adenosine triphosphatase (H/K ATPase) enzyme system
- Onset of the antisecretory effect occurs within one hour
- Maximum effect occurs within two hours
- Inhibition of secretion lasts up to 72 hours
- Secretory activity returns gradually after discontinuation
Dosage
- 20 mg once daily for benign gastric and duodenal ulcer
- 20 mg once daily for NSAID-associated duodenal or gastric ulcer
- 20 mg once daily for gastro-esophageal reflux disease
- 10-20 mg daily for long-term management of acid reflux disease
- 10-20 mg once daily for acid-related dyspepsia
- 40 mg on the preceding evening for prophylaxis of acid aspiration
- 60 mg once daily for Zollinger-Ellison syndrome
- Paeditaric use in severe ulcerating reflux esophagitis
Administration
- IV Injection should be given as a slow intravenous injection
- IV Infusion should be given over a period of 20-30 minutes or more
- IV solution should be used within 4 hours of reconstitution
- IV infusion solution should be used within 12 hours when dissolved in saline and within 6 hours when dissolved in 5% Dextrose
- Reconstituted solution should not be mixed with any other drug
Interaction
- Decreased intragastric acidity may reduce the absorption of ketoconazole
- Metabolized in the liver through cytochrome P450
- Can delay the elimination of diazepam, phenytoin, and warfarin
- Monitoring of patients receiving warfarin or phenytoin is recommended
- Plasma concentrations of HK and clarithromycin are increased during concomitant administration
Contraindications
- Known hypersensitivity to omeprazole
- When gastric ulcer is suspected, the possibility of malignancy should be excluded before treatment
Side Effects
- Skin rash, urticaria, and pruritus
- Photosensitivity, bullous eruption, and erythema multiforme
- Diarrhoea and headache
- Gastrointestinal reactions like constipation, nausea/vomiting, flatulence, and abdominal pain
- Dizziness, light headedness, and feeling faint
- Arthritic and myalgic symptoms
- Increases in liver enzymes
Pregnancy & Lactation
- Omeprazole can be used during pregnancy
- Breast-feeding should be discontinued if essential
Precautions & Warnings
- Avoid concomitant use of clopidogrel and HK
- PPI therapy may be associated with an increased risk for osteoporosis-related fractures
- Atrophic gastritis has been noted occasionally in gastric corpus biopsies from patients treated long-term with HK
Therapeutic Class
- Proton Pump Inhibitor
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children
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