Losectil 10 mg (Capsule (Enteric Coated))
Unit Price: ৳ 3.00 (12 x 10: ৳ 360.00)
Strip Price: ৳ 30.00
Medicine Details
Category | Details |
---|---|
Generic | Omeprazole |
Company | Eskayef pharmaceuticals ltd |
Also available as |
Indications
- Gastric and duodenal ulcer
- NSAID-associated duodenal and gastric ulcer
- Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
- Gastro-esophageal reflux disease
- Long-term management of acid reflux disease
- Acid-related dyspepsia
- Severe ulcerating reflux esophagitis
- Prophylaxis of acid aspiration during general anesthesia
- Zollinger-Ellison syndrome
- Helicobacter pylori-induced peptic ulcer
Pharmacology
- Inhibitor of gastric acid secretion
- Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
- Onset of antisecretory effect within one hour
- Maximum effect within two hours
- Inhibition of secretion lasts up to 72 hours
- Gradual return of secretory activity over 3 to 5 days after discontinuation
Dosage
- 20 mg once daily for benign gastric and duodenal ulcer
- 20 mg once daily for NSAID-associated duodenal or gastric ulcer
- 20 mg once daily for gastro-esophageal reflux disease
- 10-20 mg daily for long-term management of acid reflux disease
- 10-20 mg once daily for acid-related dyspepsia
- 40 mg on the preceding evening for prophylaxis of acid aspiration
- 60 mg once daily for Zollinger-Ellison syndrome
- 20 mg twice daily for Helicobacter pylori eradication regimen
- 10-20 mg once daily for severe ulcerating reflux esophagitis (Child>1 year)
- 40 mg as intravenous injection for prophylaxis of acid aspiration
- 40 mg intravenously for duodenal ulcer, gastric ulcer or reflux esophagitis
- 60 mg daily for Zollinger-Ellison syndrome (intravenous)
Administration
- Omeprazole IV injection for intravenous administration only
- Omeprazole IV injection given as a slow intravenous injection
- Omeprazole IV infusion given as intravenous infusion over a period of 20-30 minutes or more
Interaction
- Decreased intragastric acidity affecting absorption of ketoconazole
- Metabolized in the liver through cytochrome P450
- Possible delay in elimination of diazepam, phenytoin, and warfarin
- Increased plasma concentrations during concomitant administration with clarithromycin
- No evidence of interaction with phenacetin, theophylline, caffeine, and more
Contraindications
- Known hypersensitivity to omeprazole
- Suspected gastric ulcer with possibility of malignancy
Side Effects
- Well tolerated with generally mild and reversible adverse reactions
- Reported cases of skin rash, urticaria, pruritus, photosensitivity, and more
Pregnancy & Lactation
- No adverse effects reported on pregnancy or newborn child
- Use during pregnancy considered safe
- No information available on passage into breast milk
- Discontinuation of breast-feeding if essential use is considered
Precautions & Warnings
- Avoid concomitant use with clopidogrel
- Possible association with increased risk of osteoporosis-related fractures
- Atrophic gastritis noted occasionally in long-term treatment
- Risk of methotrexate toxicities with concomitant use
Therapeutic Class
Proton Pump Inhibitor
Storage Conditions
Keep in a dry place away from light and heat. Keep out of the reach of children.
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