Tenobis Plus 5 mg+6.25 mg (Tablet)

Indications

• Treatment of Hypertension

Pharmacology

• Additive antihypertensive effects
• Low incidence of hypokalemia
• Bisoprolol Fumarate: β1-selective adrenoceptor blocking agent
• Hydrochlorothiazide: Benzothiadiazine diuretic

Dosage & Administration

• Effective doses of Bisoprolol: 2.5 to 40 mg
• Effective doses of Hydrochlorothiazide: 12.5 to 50 mg
• Antihypertensive effects increase with increasing doses
• Initial therapy with one 2.5/6.25 mg tablet once daily
• Maximum recommended dose: 20/12.5 mg once daily

Interaction

• Potentiation of action of other antihypertensive agents
• Should not be combined with other beta-blocking agents
• Close monitoring with catecholamine-depleting drugs
• Caution with myocardial depressants or inhibitors of AV conduction
• Increased risk of bradycardia with concomitant use of digitalis glycosides and beta-blockers

Contraindications

• Cardiogenic shock
• Overt cardiac failure
• Second or third degree AV block
• Marked sinus bradycardia
• Anuria
• Hypersensitivity to either component or other sulfonamide-derived drugs

Side Effects

• Fatigue
• Dizziness
• Headache
• Bradycardia
• Arrhythmia
• Peripheral ischemia
• Chest pain
• Palpitations
• Cold extremities
• Orthostatic hypotension
• Diarrhoea
• Constipation
• Nausea
• Dyspepsia
• Rhinitis
• Pharyngitis

Pregnancy & Lactation

• Pregnancy Category C
• Use only if potential benefit justifies risk to the fetus
• Not studied in nursing mothers
• Thiazides excreted in human breast milk
• Small amounts detected in lactating rats' milk

Precautions & Warnings

• Potential for hyperuricemia or acute gout
• Warning signs of fluid and electrolyte imbalance
• Development of hypokalemia
• Gradual withdrawal of therapy recommended
• Careful observation of patients

Overdose Effects

• Bradycardia and hypotension
• Lethargy
• Delirium, coma, convulsions, respiratory arrest with severe overdoses
• Congestive heart failure, bronchospasm, hypoglycemia may occur
• Acute loss of fluid and electrolytes
• Cardiovascular, neuromuscular, gastrointestinal, renal, and laboratory signs and symptoms

Therapeutic Class

• Combined antihypertensive preparations

Storage Conditions

• Keep below 30°C
• Away from light & moisture
• Keep out of the reach of children

Related Brands

• Bisten Plus 2.5 mg+6.25 mg (Tablet) - edruc-limited
• Bisten Plus 5 mg+6.25 mg (Tablet) - edruc-limited
• Bisten Plus 10 mg+6.25 mg (Tablet) - edruc-limited
• Cardobis Plus 2.5 mg+6.25 mg (Tablet) - eskayef-pharmaceuticals-ltd
• Cardobis Plus 5 mg+6.25 mg (Tablet) - eskayef-pharmaceuticals-ltd