Bisten Plus 5 mg+6.25 mg (Tablet)

Unit Price: ৳ 9.00 (30's pack: ৳ 270.00)

Medicine Details

Category Details
Generic Bisoprolol fumarate hydrochlorothiazide
Company Edruc limited
Also available as
Bisten plus 25 mg tablet Bisten plus 10 mg tablet

Title and Categories

  • Bisoprolol plus Hydrochlorothiazide
  • Combination antihypertensive medication
  • Hypertension treatment

Function and Usage

  • Treatment of hypertension
  • Antihypertensive effects additive
  • Effects increase with increasing doses
  • Initial therapy with lowest dose tablet
  • Replacement therapy for individual components
  • Therapy guided by clinical effect
  • Potentiate action of other antihypertensive agents
  • Cautious use with myocardial depressants
  • Contraindicated in cardiogenic shock and overt cardiac failure
  • Pregnancy category C
  • Use in nursing mothers
  • Precautions for hyperuricemia or acute gout
  • Limited data on overdose effects

Dosage and Administration

  • Bisoprolol effective in 2.5 to 40 mg doses
  • Hydrochlorothiazide effective in 12.5 to 50 mg doses
  • Initial therapy with one 2.5/6.25 mg tablet once daily
  • Subsequent titration at 14 day intervals
  • Maximum recommended dose 20/12.5 mg once daily
  • Storage below 30°C, away from light and moisture

Pharmacology

  • Bisoprolol Fumarate is a β1-selective adrenoceptor blocking agent
  • Hydrochlorothiazide is a benzothiadiazine diuretic
  • Thiazides affect renal tubular mechanisms of electrolyte reabsorption
  • Increase excretion of sodium and chloride
  • Lower incidence of hypokalemia with combination

Interaction

  • Potentiate action of other antihypertensive agents
  • Not to be combined with other beta-blocking agents
  • Cautious use with concomitant therapy with clonidine
  • Cautious use with myocardial depressants and inhibitors of AV conduction
  • Concomitant use with digitalis glycosides increases risk of bradycardia

Contraindications

  • Cardiogenic shock
  • Overt cardiac failure
  • Second or third degree AV block
  • Marked sinus bradycardia
  • Anuria
  • Hypersensitivity to either component

Side Effects

  • Fatigue
  • Dizziness
  • Headache
  • Bradycardia
  • Arrhythmia
  • Peripheral ischemia
  • Chest pain
  • Palpitations
  • Cold extremities
  • Claudication
  • Orthostatic hypotension
  • Diarrhea
  • Constipation
  • Nausea
  • Dyspepsia
  • Rhinitis
  • Pharyngitis

Pregnancy and Lactation

  • Pregnancy Category C
  • Use in nursing mothers

Precautions and Warnings

  • Hyperuricemia or acute gout
  • Warning signs or symptoms of fluid and electrolyte imbalance
  • Hypokalemia may develop
  • Gradual withdrawal of therapy if planned

Overdose Effects

  • Bradycardia
  • Hypotension
  • Lethargy
  • Delirium
  • Coma
  • Convulsions
  • Respiratory arrest
  • Congestive heart failure
  • Bronchospasm
  • Hypoglycemia
  • Acute loss of fluid and electrolytes

Therapeutic Class

  • Combined antihypertensive preparations

Storage Conditions

  • Keep below 30°C
  • Away from light and moisture

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