Cardobis Plus 2.5 mg+6.25 mg (Tablet)

Unit Price: ৳ 7.00 (3 x 10: ৳ 210.00)
Strip Price: ৳ 70.00

Medicine Details

Category Details
Generic Bisoprolol fumarate hydrochlorothiazide
Company Eskayef pharmaceuticals ltd
Also available as
Cardobis plus 5 mg tablet

Title

Bisoprolol plus Hydrochlorothiazide Tablets

Categories

  • Medicine
  • Antihypertensive
  • Combination Therapy

Description

Bisoprolol plus Hydrochlorothiazide is indicated for the treatment of hypertension. It contains Bisoprolol Fumarate, a cardioselective adrenoceptor blocking agent, and Hydrochlorothiazide, a benzothiadiazine diuretic. The combination therapy has additive antihypertensive effects with a lower incidence of hypokalemia compared to Hydrochlorothiazide alone. The product is available in various doses and is suitable for initial, replacement, and therapy guided by clinical effect.

Attributes

  • Therapeutic Class:
    • Combined antihypertensive preparations
  • Indications:
    • Treatment of hypertension
  • Pharmacology:
    • Additive antihypertensive effects
    • Low incidence of hypokalemia
    • Mechanism of action of individual components
  • Dosage & Administration:
    • Doses of Bisoprolol (2.5 to 40 mg) and Hydrochlorothiazide (12.5 to 50 mg)
    • Initial Therapy with lowest dose (2.5/6.25 mg)
    • Subsequent titration
    • Replacement Therapy
    • Therapy guided by clinical effect
  • Interaction:
    • Potentiate the action of other antihypertensive agents
    • Interaction with beta-blocking agents
    • Monitoring with catecholamine-depleting drugs
    • Caution with concurrent use of clonidine, myocardial depressants, AV conduction inhibitors, and digitalis glycosides
  • Contraindications:
    • Cardiogenic shock
    • Overt cardiac failure
    • Second or third degree AV block
    • Marked sinus bradycardia
    • Anuria
    • Hypersensitivity to either component or other sulfonamide-derived drugs
  • Side Effects:
    • Mild and transient side effects
    • Fatigue
    • Dizziness
    • Headache
    • Bradycardia
    • Arrhythmia
    • Peripheral ischemia
    • Chest pain
    • Palpitations
    • Cold extremities
    • Orthostatic hypotension
    • Gastrointestinal disturbances
  • Pregnancy & Lactation:
    • Pregnancy Category C
    • Use only if potential benefit justifies risk to fetus
    • Excretion in human breast milk
    • Potential for serious adverse reactions in nursing infants
  • Precautions & Warnings:
    • Hyperuricemia or acute gout
    • Fluid and electrolyte imbalance warning signs
    • Hypokalemia
    • Gradual withdrawal of therapy
    • Careful observation of patients
  • Overdose Effects:
    • Signs of overdose with beta-blocker
    • Signs of acute loss of fluid and electrolytes with thiazide diuretics
    • Bradycardia, hypotension, lethargy, delirium, coma, convulsions, respiratory arrest
    • Congestive heart failure, bronchospasm, hypoglycemia
  • Storage Conditions:
    • Keep below 30°C temperature
    • Away from light & moisture
    • Out of the reach of children

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