Losectil 40 mg (Capsule (Enteric Coated))
Unit Price: ৳ 9.00 (6 x 10: ৳ 540.00)
Strip Price: ৳ 90.00
Medicine Details
Category | Details |
---|---|
Generic | Omeprazole |
Company | Eskayef pharmaceuticals ltd |
Also available as |
Indications
- Gastric and duodenal ulcer
- NSAID-associated duodenal and gastric ulcer
- Prophylaxis in patients with a history of NSAID-associated ulcers
- Gastro-esophageal reflux disease
- Long-term management of acid reflux disease
- Acid-related dyspepsia
- Severe ulcerating reflux esophagitis
- Prophylaxis of acid aspiration during general anesthesia
- Zollinger-Ellison syndrome
- Helicobacter pylori-induced peptic ulcer
Pharmacology
- Inhibitor of gastric acid secretion
- Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
- Onset of antisecretory effect within one hour
- Maximum effect occurring within two hours
- Inhibition of secretion lasts up to 72 hours
Dosage
- Dosage for benign gastric and duodenal ulcer
- Dosage for NSAID-associated duodenal or gastric ulcer
- Dosage for gastro-esophageal reflux disease
- Dosage for long-term management of acid reflux disease
- Dosage for acid-related dyspepsia
- Dosage for prophylaxis of acid aspiration
- Dosage for Zollinger-Ellison syndrome
- Dosage for Helicobacter pylori eradication regimen
- Pediatric use in severe ulcerating reflux esophagitis
Administration
- IV Injection direction
- IV Infusion direction
- Directions for reconstituting and administering IV injection
- Directions for reconstituting and administering IV infusion
Interaction
- Effect on absorption of ketoconazole
- Metabolism through cytochrome P450
- Interaction with diazepam, phenytoin, and warfarin
- Plasma concentrations of Losectil and clarithromycin during concomitant administration
- Effect on absorption of phenacetin, theophylline, caffeine, propranolol, metoprolol, cyclosporin, lidocaine, quinidine, estradiol, amoxycillin, antacids, piroxicam, diclofenac, naproxen, digoxin
Contraindications
- Known hypersensitivity to omeprazole
- Suspicion of gastric ulcer with possibility of malignancy
Side Effects
- Skin rash, urticaria, pruritus
- Photosensitivity, bullous eruption, erythema multiforme, angioedema, alopecia
- Diarrhoea, headache
- Constipation, nausea/vomiting, flatulence, abdominal pain
- Dry mouth, stomatitis, candidiasis
- Paraesthesia
- Dizziness, light headedness, feeling faint
- Somnolence, insomnia, vertigo
- Mental confusion, agitation, depression, hallucinations
- Arthritic and myalgic symptoms
- Blurred vision, taste disturbance, peripheral edema
- Increased sweating, gynaecomastia, leucopenia, thrombocytopenia
- Agranulocytosis, pancytopenia, anaphylactic shock
- Malaise, fever, bronchospasm
- Encephalopathy in patients with pre-existing severe liver disease, hepatitis, interstitial nephritis, hepatic failure
- Increases in liver enzymes
Pregnancy & Lactation
- No adverse effects on pregnancy or fetus/newborn child
- No information on passage into breast milk or effects on neonate
- Discontinuation of breastfeeding if essential
Precautions & Warnings
- Avoid concomitant use with clopidogrel
- Associations with increased risk for osteoporosis-related fractures
- Atrophic gastritis in patients treated long-term
- Concomitant use with methotrexate
Therapeutic Class
- Proton Pump Inhibitor
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children
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