Losectil 20 mg/sachet (Oral Powder)
20 mg sachet: ৳ 6.00 (50's pack: ৳ 300.00)
Medicine Details
Category | Details |
---|---|
Generic | Omeprazole |
Company | Eskayef pharmaceuticals ltd |
Also available as |
Indications
- Gastric and duodenal ulcer
- NSAID-associated duodenal and gastric ulcer
- Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
- Gastro-esophageal reflux disease
- Long-term management of acid reflux disease
- Acid-related dyspepsia
- Severe ulcerating reflux esophagitis
- Prophylaxis of acid aspiration during general anesthesia
- Zollinger-Ellison syndrome
- Helicobacter pylori-induced peptic ulcer
Pharmacology
Inhibitor of gastric acid secretion
Dosage
- 20 mg once daily for duodenal ulceration
- 40 mg daily for severe or recurrent cases
- 10-20 mg daily for prevention of relapse in duodenal ulcer
- 20 mg once daily for 4 weeks for gastro-esophageal reflux disease
- 40 mg once daily for 8 weeks in refractory cases of gastro-esophageal reflux disease
- 10-20 mg daily for long-term management of acid reflux disease
- 10-20 mg once daily for 2-4 weeks for acid-related dyspepsia
- 40 mg on the preceding evening and 2-6 hours before surgery for prophylaxis of acid aspiration
- 60 mg once daily for Zollinger-Ellison syndrome
- 20 mg twice daily in Helicobacter pylori eradication regimen
- 10-20 mg once daily for 4-12 weeks for pediatric use in severe ulcerating reflux esophagitis
Administration
- For IV Injection: Slow intravenous injection over 2 to 5 minutes
- For IV Infusion: Over a period of 20-30 minutes or more
- Solution for IV infusion should be used within 12 hours when dissolved in saline and within 6 hours when dissolved in 5% Dextrose
Interaction
- Decreased intragastric acidity may reduce absorption of ketoconazole
- Metabolized in the liver through cytochrome P450, may delay elimination of diazepam, phenytoin, and warfarin
- Plasma concentrations of Losectil and clarithromycin are increased during concomitant administration
- No evidence of interaction with phenacetin, theophylline, caffeine, propranolol, metoprolol, cyclosporin, lidocaine, quinidine, estradiol, amoxycillin, antacids, piroxicam, diclofenac, naproxen, alcohol, or food
Contraindications
Hypersensitivity to Omeprazole, suspicion of gastric ulcer with possibility of malignancy
Side Effects
- Skin rash, urticaria, pruritus
- Photosensitivity, bullous eruption, erythema multiforme, angioedema, alopecia
- Diarrhea, headache
- Gastrointestinal reactions such as constipation, nausea/vomiting, flatulence, abdominal pain
- Paraesthesia, dizziness, light headedness, faint feeling
- Somnolence, insomnia, vertigo
- Reversible mental confusion, agitation, depression, hallucinations
- Arthritic and myalgic symptoms
- Blurred vision, taste disturbance, peripheral edema, increased sweating, gynaecomastia
- Leucopenia, thrombocytopenia, agranulocytosis, pancytopenia, anaphylactic shock, malaise, fever
- Encephalopathy, hepatitis, interstitial nephritis, hepatic failure
- Increases in liver enzymes
Pregnancy & Lactation
Omeprazole can be used during pregnancy, no information available on passage into breast milk or its effects on the neonate
Precautions & Warnings
- Avoid concomitant use with clopidogrel
- PPI therapy may be associated with increased risk for osteoporosis-related fractures
- Atrophic gastritis noted in long-term treatment
- Concomitant use with methotrexate may lead to methotrexate toxicities
Therapeutic Class
Proton Pump Inhibitor
Storage Conditions
Keep in a dry place away from light and heat, keep out of the reach of children
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