Losek 20 mg (Capsule (Enteric Coated))
Unit Price: ৳ 4.00 (60's pack: ৳ 240.00)
Medicine Details
Category | Details |
---|---|
Generic | Omeprazole |
Company | Bristol pharmaceuticals ltd |
Also available as |
Indications
- Gastric and duodenal ulcer
- NSAID-associated duodenal and gastric ulcer
- Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
- Gastro-esophageal reflux disease
- Long-term management of acid reflux disease
- Acid-related dyspepsia
- Severe ulcerating reflux esophagitis
- Prophylaxis of acid aspiration during general anesthesia
- Zollinger-Ellison syndrome
- Helicobacter pylori-induced peptic ulcer
Pharmacology
- Inhibitor of gastric acid secretion
- Inhibits gastric acid secretion by blocking H+/K+ ATPase enzyme system
- Onset of antisecretory effect within one hour
- Maximum effect occurring within two hours
- Inhibition of secretion lasts up to 72 hours
- Secretory activity returns gradually over 3 to 5 days after discontinuation
Dosage
- Dosage for benign gastric and duodenal ulcer
- Dosage for NSAID-associated duodenal or gastric ulcer
- Dosage for gastro-esophageal reflux disease
- Dosage for long-term management of acid reflux disease
- Dosage for acid-related dyspepsia
- Dosage for prophylaxis of acid aspiration
- Dosage for Zollinger-Ellison syndrome
- Dosage for Helicobacter pylori eradication regimen in peptic ulcer disease
- Paediatric use in severe ulcerating reflux esophagitis
Administration
- IV Injection administration
- IV Infusion administration
- Direction for use of IV Injection
- Direction for use of IV Infusion
- Reconstitution of IV injection
- Reconstitution of IV infusion
- Instructions for slow intravenous injection
- Maximum rate of IV injection
- Freshly prepared solution required
- Use within specified time after reconstitution
- Instructions for intravenous infusion over a period of 20-30 minutes or more
- Instructions for dissolved in saline or 5% Dextrose for infusion
- Reconstituted solution should not be mixed or co-administered with any other drug
Interaction
- Decreased intragastric acidity affecting absorption of ketoconazole
- Metabolism in the liver through cytochrome P450
- Possible delay in elimination of diazepam, phenytoin, and warfarin
- Plasma concentrations of Omeprazole and clarithromycin
- No evidence of interaction with phenacetin, theophylline, caffeine, propranolol, metoprolol, cyclosporin, lidocaine, quinidine, estradiol, amoxycillin, or antacids
- No effect on absorption by alcohol or food
- Increase in bioavailability of digoxin with simultaneous treatment
Contraindications
- Known hypersensitivity to omeprazole
- Suspicion of gastric ulcer should exclude the possibility of malignancy before treatment
Side Effects
- Skin rash, urticaria and pruritus
- Photosensitivity and bullous eruption
- Diarrhoea and headache
- Constipation, nausea/vomiting, flatulence, and abdominal pain
- Dry mouth, stomatitis, and candidiasis
- Paraesthesia
- Dizziness, light headedness, and feeling faint
- Somnolence, insomnia, and vertigo
- Reversible mental confusion, agitation, depression, and hallucinations
- Arthritic and myalgic symptoms
- Blurred vision, taste disturbance, and peripheral oedema
- Increase in liver enzymes
Pregnancy & Lactation
- No adverse effects of omeprazole on pregnancy or fetus/newborn child indicated by epidemiological studies
- Use during pregnancy possible
- No information available on passage into breast milk or effects on the neonate
- Use of omeprazole essential warrants discontinuation of breastfeeding
- Safety and effectiveness not established in pediatric patients less than 18 years of age
Precautions & Warnings
- Avoid concomitant use of clopidogrel and omeprazole
- Increased risk for osteoporosis-related fractures with PPI therapy
- Atrophic gastritis occasionally noted in long-term treatment with omeprazole
- Concomitant use with methotrexate may lead to methotrexate toxicities
Therapeutic Class
- Proton Pump Inhibitor
Storage Conditions
- Dry place away from light and heat
- Keep out of the reach of children
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