Losek 40 mg (Capsule (Enteric Coated))
Unit Price: ৳ 7.00 (30's pack: ৳ 210.00)
Medicine Details
Category | Details |
---|---|
Generic | Omeprazole |
Company | Bristol pharmaceuticals ltd |
Also available as |
Indications
- Gastric and duodenal ulcer
- NSAID-associated duodenal and gastric ulcer
- Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
- Gastro-esophageal reflux disease
- Long-term management of acid reflux disease
- Acid-related dyspepsia
- Severe ulcerating reflux esophagitis
- Prophylaxis of acid aspiration during general anesthesia
- Zollinger-Ellison syndrome
- Helicobacter pylori-induced peptic ulcer
Pharmacology
- Inhibitor of gastric acid secretion
- Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
- Onset of antisecretory effect within one hour
- Maximum effect occurring within two hours
- Inhibition of secretion lasts up to 72 hours
- Gradual return of secretory activity over 3 to 5 days after discontinuation
Dosage
- Dosage varies based on condition and severity
- Oral and IV administration
- Dosage for benign gastric and duodenal ulcer
- Dosage for NSAID-associated duodenal or gastric ulcer
- Dosage for gastro-esophageal reflux disease
- Dosage for long-term management of acid reflux disease
- Dosage for acid-related dyspepsia
- Dosage for prophylaxis of acid aspiration
- Dosage for Zollinger-Ellison syndrome
- Dosage for Helicobacter pylori eradication regimen in peptic ulcer disease
- Pediatric use in severe ulcerating reflux esophagitis
Administration
- Direction for use of IV Injection
- Direction for use of IV Infusion
- Instructions for reconstitution of IV injection and infusion
- Stability guidelines for reconstituted solution
- No other route of administration
Interaction
- Impact on absorption of ketoconazole
- Metabolism through cytochrome P450 affecting other drugs
- Potential interaction with warfarin, phenytoin, and diazepam
- Impact on plasma concentrations when co-administered with clarithromycin
- No interaction with various drugs such as theophylline, caffeine, and antacids
Contraindications
- Known hypersensitivity to Omeprazole
- Need to exclude malignancy before treatment
Side Effects
- Skin reactions including rash, urticaria, and pruritus
- Photosensitivity, bullous eruption, and erythema multiforme
- Gastrointestinal reactions like diarrhea and constipation
- Headache, dizziness, and somnolence
- Mental confusion, agitation, and depression
- Arthritic and myalgic symptoms
- Potential liver-related adverse effects
Pregnancy & Lactation
- No adverse effects on pregnancy or fetus/newborn child
- Use during pregnancy with caution
- No information available for passage into breast milk
- Discontinuation of breast-feeding if essential
Precautions & Warnings
- Avoid concomitant use of clopidogrel
- Possible association with increased risk for osteoporosis-related fractures
- Atrophic gastritis noted in long-term treatment
- Potential methotrexate toxicities with concomitant use of PPIs
Therapeutic Class
Proton Pump Inhibitor
Storage Conditions
Keep in a dry place away from light and heat
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